| PTTG、MMP-2在人脑星形细胞瘤中的表达及意义 |
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| 引用本文： | 季玉陈,牛光明,张鹏远,娄金锋,周兴,常克亮,陶胜忠,苏芳忠. PTTG、MMP-2在人脑星形细胞瘤中的表达及意义[J]. 中国实用神经疾病杂志, 2011, 14(15): 9-11 |
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| 作者姓名： | 季玉陈 牛光明 张鹏远 娄金锋 周兴 常克亮 陶胜忠 苏芳忠 |
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| 作者单位： | 郑州大学第二附属医院神经外科,郑州,450014 |
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| 摘 要： | 目的探讨PTTG、MMP-2在人脑星形细胞瘤中的表达,研究其与病理分级的关系,分析二者在表达过程中的相互关系。方法采用免疫组织化学S-P法检测PTTG、MMP-2在正常脑组织及在不同病理级别人脑星形细胞瘤中的表达。结果 PTTG、MMP-2在2组阳性表达比较差异有统计学意义(P<0.05),表达阳性率随病理级别的增高呈增高趋势,低度恶性组与恶性组比较差异有统计学意义(P<0.05),而恶性组与高度恶性组比较差异无统计学意义(P>0.05),二者在表达过程中存在正相关(r=0.504,P<0.05)。结论 PTTG和MMP-2在人脑星形细胞瘤的发生发展过程中存在正相关性,PTTG可能通过MMP-2促进肿瘤的发生和发展。
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| 关 键 词： | 星形细胞瘤 PTTG MMP-2 免疫组织化学 |
Expressions of PTTG and MMP-2 and their significance in human astrocytomas |
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| Ji Yuchen,Niu Guangming,Zhang Pengyuan,et al.. Expressions of PTTG and MMP-2 and their significance in human astrocytomas[J]. Chinese Journal of Practical Neruous Diseases, 2011, 14(15): 9-11 |
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| Authors: | Ji Yuchen Niu Guangming Zhang Pengyuan et al. |
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| Affiliation: | Ji Yuchen,Niu Guangming,Zhang Pengyuan,et al.Department of Neurosurgery,the Second Affiliated Hospital of Zhengzhou University,ZhengZhou 450014,China |
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| Abstract: | Objective To detect the expressions of PTTG and MMP-2 in human astrocytoma and the relationship between the two proteins.Methods S-P immunohistochemistry was used to detect the expressions of PTTG and MMP-2 in human astrocytoma with different pathology grades.Results Positive expressions were found in all different malignant grades tumors.The expression levels of PTTG and MMP-2 were positively correlative with the malignant grades(P<0.05).There was a positive relationship between PTTG and MMP-2(r=0.504,P<0.... |
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| Keywords: | Astrocytom PTTG MMP-2 Immunohistochemistry |
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