| 动脉瘤性蛛网膜下腔出血血管内栓塞后D-dimer浓度变化与预后的关系 |
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| 引用本文： | 王运良,曾志磊,尹红蕾,韩冰,张辉,刘亚军,娄季宇.动脉瘤性蛛网膜下腔出血血管内栓塞后D-dimer浓度变化与预后的关系[J].中国实用神经疾病杂志,2011,14(16):4-7. |
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| 作者姓名： | 王运良 曾志磊 尹红蕾 韩冰 张辉 刘亚军 娄季宇 |
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| 作者单位： | 1. 解放军第一四八中心医院神经内科,淄博,255300
2. 郑州大学第二附属医院神经内科,郑州,450014 |
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| 摘 要： | 目的探讨动脉瘤性蛛网膜下腔出血(SAH)血管内栓塞后D-dimer浓度的变化以及D-dimer浓度升高能否做为预后不良的独立预测因素。方法对204例发病48 h内入住我院和郑州大学第二附属医院神经内科的SAH病人,在手术当天早晨和动脉瘤填塞后14 d检测血浆D-dimer浓度,3个月时根据格拉斯哥预后评分和CT随访脑梗塞的发生做为预后不良的预测因素。结果动脉瘤栓塞后预后不良的病人较预后良好者D-dimer浓度明显升高,手术当天2组各自平均为(1 368±298)μg/L和(756±144)μg/L,14 d时分别为(1 129±166)μg/L和(356±73)μg/L,P<0.001。重复检测发现,预后良好者D-dimer浓度降低较快,排除其他影响因素后,D-dimer与预后不良有明显关系。结论 SAH后血浆D-dimer升高是预后不良的独立预测因素,可能与凝血酶代谢产物过量积聚引起的损害有关。
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| 关 键 词： | 动脉瘤 蛛网膜下腔出血 D-二聚体 纤维蛋白溶解 |
Relationships between the concentrations of D-dimer and prognosis after intravascular embolization treatment with aneurismal subarachnoid hemorrhage |
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| Wang Yunliang,Zeng Zhilei,Yin Honglei,et al..Relationships between the concentrations of D-dimer and prognosis after intravascular embolization treatment with aneurismal subarachnoid hemorrhage[J].Chinese Journal of Practical Neruous Diseases,2011,14(16):4-7. |
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| Authors: | Wang Yunliang Zeng Zhilei Yin Honglei |
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| Institution: | Wang Yunliang,Zeng Zhilei,Yin Honglei,et al.Department of Neurology,the 148 Central Hospital of PLA,Zibo 255300,China |
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| Abstract: | Objective To explore the changes of D-dimer levels in patients with subarachnoid hemorrhage(SAH) after intravascular embolization treatment,and whether elevated D-dimer levels is a predictor independently of poor outcome.Methods Two hundred and four patients with SAH were admitted in our hospital and the Second Affiliated Hospital of Zhengzhou University within 48 hours after bleeding,plasma D-dimer was measured in the morning of aneurisma occlusion and at the 14 days after SAH.Factors predicting poor outco... |
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| Keywords: | Aneurism Subarachnoid hemorrhage D-dimer Fibrinolysis |
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