应用Logistic回归分析炎性因子与子痫前期孕妇病情的相关性

目的:探讨子痫前期(PE)孕妇血清炎性因子IL-17、C反应蛋白(CRP)、血浆淀粉样蛋白A(SAA)的水平变化及与病情的相关性。方法:选取75例子痫前期孕妇作为观察组,其中包括45例轻度子痫患者和30例重度子痫患者,同时选取同期在本院查体的30例健康孕妇作为对照组。用酶联免疫吸附法(ELISA)测定IL-17、SAA的含量,用免疫比浊法测定CRP的含量。应用Logistic回归分析各指标与疾病严重程度的相关性。结果:PE孕妇血清中CRP、IL-17和SAA含量显著高于对照组,重度PE孕妇血清CRP、IL-17和SAA含量显著高于轻度组(P<0. 05); Logistic回归分析证实CRP、IL-17和SAA与PE病情具有密切关联(P<0. 05)。三者联合检测诊断价值最高。结论:血清CRP、IL-17和SAA参与了PE的发生、发展,可作为判断疾病轻重的指标,为早期检测及治疗提供有利的依据。

Analysis of correlation between inflammatory factors and pre-eclampsia pregnancy with logistic regression

Objective:To detect the levels of CRP,IL-17 and SAA in pre-eclampsia women in pregnancy and to explore the relationship between them and the disease.Methods:A tota1 of 75 pregnant women with PE(45 mild cases and 30 severe cases confirmed)were enrolled in observation group and 30 healthy women(through professional inspection)were recruited in control group.The levels of CRP were detected by immune turbidimetric assay and the levels of IL-17 and SAA were detected by ELISA.Logistic regression analysis was used to analyze the correlation between various indicators and disease severity.Results:The serum levels of CRP,IL-17 and SAA were significantly higher in pre-eclampsia women group than those in control group.The serum levels of CRP,IL-17 and SAA were significantly higher in severe cases than those in mild cases.Logistic correlation analysis showed that the serum levels of CRP,IL-17 and SAA are closely related to preeclampsia(P<0.05).The combined detection of the three has the highest diagnostic value.Conclusion:Serum C,IL-17 and SAA are involved in the occurrence and development of PE,which can be used as indicators to judge the severity of diseases and provide favorable basis for early detection and treatment.