| 上海市某医院新生儿脐带血中多溴联苯醚水平及其对出生结局的影响 |
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| 引用本文： | 张琳,田英,杨先丰,崔昌,高宇,王筱金,王沛,丁问微,施蓉,王英,金军,金萍. 上海市某医院新生儿脐带血中多溴联苯醚水平及其对出生结局的影响[J]. 中华预防医学杂志, 2010, 45(8): 490-493. DOI: 10.3760/cma.j.issn.0253-9624.2011.06.004 |
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| 作者姓名： | 张琳 田英 杨先丰 崔昌 高宇 王筱金 王沛 丁问微 施蓉 王英 金军 金萍 |
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| 作者单位： | 200025,上海交通大学医学院公共卫生学院环境卫生学教研室;上海市环境与儿童健康教育部重点实验室;潍坊人民医院滨海分院;上海交通大学医学院公共卫生学院环境卫生学教研室,200025;上海交通大学医学院公共卫生学院生物统计学教研室,200025;上海市浦东新区疾病预防控制中心高桥分中心;中央民族大学生命与环境科学学院; |
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| 基金项目： | 国家自然科学基金上海市卫生局基金 |
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| 摘 要： | Objective To explore the concentration of polybrominated diphenyl ethers(PBDEs)in umbilical cord serum and analyze the influence of exposure to PBDEs during fetal stage on newborn birth outcomes in Shanghai.Methods Fifty delivery women in a Shanghai hospital were surveyed by questionnaire.and the umbilical cord serum were collected from September 2006 to April 2007.All the delivery women were singleton pregnancies,excluding hish blood pressure,diabetes,HIV infection and adverse medical history.Seven congeners(BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154 and BDE-183) were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were anatyzed. Results Newborns'length.weight,chest circumference,head circumference and body mass index(BMI)were(50.15±0.75)cm,(3.49±0.42)kg,(34.76±1.51)cm,(35.03 ±1.40)cm,(13.76±1.36)kg/m2,respectively.The median of ∑7 PBDEs concentration in umbilical cord serum was 14.06(1.03-379.73)ng/g lipid weight(1w).The detection rate of BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154 and BDE-183 were 22%(11/50),22%(11/50),98%(49/50).72%(36/50),76%(38/50),90%(45/50)and 14%(7/50),respectively.The median(range)of PBDEs (BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154,BDE-183)congeners were ＜LOD (＜LOD-137.20 ng/g 1w),＜LOD(＜LOD-33.17 ng/g 1w),7.54.ng/g 1w(＜LOD-94.01 ng/g 1w),1.57 ng/g 1w(＜LOD-46.95 ng/g 1w),0.63.ng/g 1w(＜LOD-79.08 ng/g 1w),0.63 ng/g 1w(＜LOD-22.30 ng/g 1w)and＜LOD(＜LOD-21.63 ng/g 1w),respectiveIy.The newborns'BMI showed a negative correlation with BDE-99(r=-0.347.P＜0.05)and BDE.154(r=-0.292.P＜0.05).BDE-99in low-length group(≤50 cm,10.59 ng/g 1w) was significantly higher(t=2.32,P=0.03)than that in high-length group(＞50 cm,3.60 ng/g 1w).Conclusion PBDEs were commonly detected in newborns'umbilical cord serum in this study.Our findings indicated that exposure to PBDEs adversely affected the development of the newborns.
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| 关 键 词： | 多溴联苯类 婴儿,新生 胎血 胚胎发育 |
Concentration of polybrominated diphenyl ethers in umbilical cord serum and the influence on newborns birth outcomes in Shanghai |
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| ZHANG Lin,TIAN Ying,YANG Xian-feng,CUI Chang,GAO Yu,WANG Xiao-jin,WANG Pei,DING Wen-wei,SHI Rong,WANG Ying,JIN Jun,JIN Ping. Concentration of polybrominated diphenyl ethers in umbilical cord serum and the influence on newborns birth outcomes in Shanghai[J]. Chinese Journal of Preventive Medicine, 2010, 45(8): 490-493. DOI: 10.3760/cma.j.issn.0253-9624.2011.06.004 |
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| Authors: | ZHANG Lin TIAN Ying YANG Xian-feng CUI Chang GAO Yu WANG Xiao-jin WANG Pei DING Wen-wei SHI Rong WANG Ying JIN Jun JIN Ping |
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| Abstract: | |
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| Keywords: | Polybrominated biphenylsInfant newbornFetal bloodEmbryonic development |
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