| OX40基因rs2298212位点与汉族人群冠状动脉粥样硬化疾病的关联研究 |
| |
| 引用本文： | 程广辉,王慧,马龙,张凯,黎莉,龚瑶琴,刘奇迹. OX40基因rs2298212位点与汉族人群冠状动脉粥样硬化疾病的关联研究[J]. 中华医学遗传学杂志, 2010, 27(1): 171-175. DOI: 10.3760/cma.j.issn.1003-9406.2010.02.012 |
| |
| 作者姓名： | 程广辉 王慧 马龙 张凯 黎莉 龚瑶琴 刘奇迹 |
| |
| 作者单位： | 山东大学医学院医学遗传学研究所,实验畸形学教育部重点实验室,济南,250012;山东大学医学院医学遗传学研究所,齐鲁医院心内科,济南,250012; |
| |
| 基金项目： | 国家863项目国家973项目 |
| |
| 摘 要： | Objective To study the association of the OX40 gene rs2298212G/A polymorphism with coronary atherosclerotic disease (CAD) in Chinese Han population. Methods Five hundred and thirty six CAD patients and 544 age and ethnic matched controls of Chinese Hah population were recruited from Qilu Hospital, Shandong University. Polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) was used to genotype the selected single nucleotide polymorphism. Distributions of genotypic and allelic frequencies were analyzed by Chi square test. Results The distribution of genotypic and allelic frequencies have no significant differences between the CAD cases and controls (P＞0.05), even after adjusting for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, and triglyceride. However, when substratification analysis of the involved coronary artery vessels was performed, significant difference was found between single-vessel and triple-vessel (P=0.02,OR=1.56,95%CI:1.08-2.26) involvement. Conclusion The rs2298212G/A polymorphism in OX40 gene may be associated with the severity of coronary atherosclerotic disease.
|
| 关 键 词： | OX40基因 单核苷酸多态性 冠状动脉粥样硬化 关联分析 |
Association of rs2298212 polymorphism in OX40 gene with coronary atheroscleroticdisease in Chinese Han population |
| |
| Abstract: | |
| |
| Keywords: | OX40 genesingle nucleotide polymorphismcoronary atherosclerotic diseaseassociation study |
|
|
