提取-共沸精馏耦合工艺提取川芎挥发油的研究

目的:采用提取-共沸精馏耦合新工艺(water extraction coupling rectification,WER)提取川芎挥发油,并与<中国药典>中规定的挥发油水蒸气蒸馏提取工艺(steam distillation,SD)进行挥发油得率和质量的比较.方法:分别采用WER与SD提取川芎挥发油,并对2种工艺提取的挥发油进行GC-MS分析,比较其挥发油得率和GC-MS图.结果:在相同提取条件下,WER工艺下川芎挥发油的得率0.50%是SD 0.20%的2.5倍,2种工艺下川芎挥发油的GC-MS图共有峰有21个,分别占挥发油总含量的98.94%(SD)与98.80%(WER),而且相同组分的含量差异不大.结论:采用提取-共沸精馏耦合法提取川芎挥发油不仅可以显著提高川芎的得率,而凡能够延续水蒸气蒸馏所得挥发油的品质.

Water extraction coupling rectification for isolating volatile oils of Ligusticum chuanxiong

To improve the oil yield of Chuanxiong volatile oils and keep their quality same as that of oils prepared by steam distillation (SD for short), a new technology of coupling water extraction and rectification (WER for short) was applied to isolate Chuanxiong volatile oils. The oil yield, as well as GC-MS chromatogram of the volatile oils extracted by WER and SD were compared. The oil yield of WER (0.50%) was that of SD (0.20%). There were 21 common constituents in the two kinds of volatile oils, which occupied 98.94% of the oils extracted by SD, 98.80% of that by WER, respectively. Moreover, the relative percentage of the common constituents was almost the same. The results indicate that WER could not only increase the oil yield of Ligusticum chuanxiong, but also keep the quality of the oils accord with that extracted by SD.