| 环氧合酶-2在皮肤肿瘤组织中的表达及其临床意义 |
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| 引用本文： | 曾维惠,谭升顺,雷小兵,张江安,苏宝山.环氧合酶-2在皮肤肿瘤组织中的表达及其临床意义[J].中国皮肤性病学杂志,2004,18(9):523-525. |
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| 作者姓名： | 曾维惠 谭升顺 雷小兵 张江安 苏宝山 |
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| 作者单位： | 西安交通大学第二医院皮肤科,陕西,西安,710004 |
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| 摘 要： | 目的 探讨环氧合酶 2 (COX 2 )在皮肤肿瘤组织中的表达及其临床意义。方法 应用免疫组织化学方法分别检测 82例皮肤肿瘤组织 ( 2 1例Bowen病、2 6例基底细胞癌、3 5例鳞状细胞癌 )和 10例正常皮肤组织中COX 2的表达。结果 皮肤肿瘤组织中COX 2阳性表达率为 76.83 % ,显著高于正常皮肤组织的 10 .0 0 % ( χ2 =15 .78,P <0 .0 1) ;COX 2主要表达于肿瘤细胞胞浆与核周 ;鳞状细胞癌的阳性表达与肿瘤分期无明显相关 ( χ2 =0 .70 ,P >0 .0 5 )。结论 COX 2的高表达可能与皮肤肿瘤的发生有关
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| 关 键 词： | 皮肤肿瘤 环氧合酶-2 免疫组织化学 |
| 文章编号： | 1001-7089(2004)09-0523-03 |
Expression of Cyclooxygenase -2 in Skin Carcinoma and Its Clinical Significance |
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| ZENG Wei-hui,TAN Sheng-shun,LEI Xiao-bing,et al.Expression of Cyclooxygenase -2 in Skin Carcinoma and Its Clinical Significance[J].The Chinese Journal of Dermatovenereology,2004,18(9):523-525. |
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| Authors: | ZENG Wei-hui TAN Sheng-shun LEI Xiao-bing |
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| Abstract: | Objective To study the expression of cyclooxygenase -2 (COX-2) in skin carcinoma and its clinical significance.Methods The expression of COX-2 in 82 cases of skin carcinoma(21 Bowen's disease,26 BCC,35 SCC) and 10 cases of nomal skin tissue were detected by immunohistchemical technique.Results The positive expression rate of COX-2 in skin carcinoma(76.83% )was significantly higher than that in normal skin tissue (10.00%)(χ 2=15.78,P<0.01).COX-2 immunoreactivity was localized in the carcinoma cell. The exprssion of COX-2 was not correlated with stage of squamous cell carcinoma(χ 2= 0.70,P>0.05).Conclusion The high expression of COX-2 may be invovled in carcinogenesis of skin carcinoma. |
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| Keywords: | Skin carcinoma Cyclooxygenases-2 Immunohistochemistry |
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