归苓片改善动物学习记忆功能的研究

目的研究归苓片(FBD)促进动物学习记忆功能的作用。方法小鼠ig给予35、70、140mg/kg FBD,连续1周,观察FBD对东莨菪碱所致小鼠记忆获得障碍、亚硝酸钠所致小鼠记忆巩固不良和45%乙醇致小鼠记忆再现障碍的影响,并观察FBD对大鼠双侧颈总动脉结扎所致的慢性脑部供血不足而产生的记忆障碍的改善作用。结果FBD对由东莨菪碱所致的小鼠记忆获得障碍、亚硝酸钠所致的小鼠记忆巩固不良和45%乙醇所致的小鼠记忆再现障碍均有明显的改善作用;并可改善大鼠双侧颈总动脉结扎所致的慢性脑部供血不足而产生的记忆障碍。结论FBD可促进动物的学习记忆功能。

FBD used to improve learning and memory function of animals

Objective To study on FBD (composed with Poria cocos, Atractylodes macrocephala, and Angelica sinensis) used to improve learning and memory function of animals. Methods The mice were treated by ig FBD with the doses of 35, 70 and 140 mg/kg for one week continuously. Effect of FBD on dysmnesia of acquired learning of mice induced by scopolamine, dysmnesia of memory retention of mice induced by NaNO2, and dysmnesia of reappearance of memory of mice induced by 45% ethanol were studied. Improvement for the dysmnesia of memory due to chronic blood deficiency in brain of rats induced by ligating the carotid arteries of two sides were observed. Results FBD can improve the dysmnesia of mice induced by scopolamine, NaNO2, and 45% ethanol significantly, also dysmnesia due to chronic blood deficiency in brain of rats induced by ligating the carotid arteries. Conclusion FBD has the function to improve the learning and memory function of animals.