| 四逆汤中脂类生物碱来源于酯交换反应的研究 |
| |
| 引用本文： | 王勇,宋凤瑞,刘志强,刘淑莹.四逆汤中脂类生物碱来源于酯交换反应的研究[J].医学教育探索,2006(1):51-54. |
| |
| 作者姓名： | 王勇 宋凤瑞 刘志强 刘淑莹 |
| |
| 作者单位： | 深圳大学生命科学学院深圳市微生物基因工程重点实验室 广东深圳518060(王勇)，中国科学院长春应用化学研究所新药研究室 吉林长春130024(宋凤瑞，刘志强，刘淑莹) |
| |
| 摘 要： | 目的研究附子中脂类生物碱(脂碱)的溶解性,确定四逆汤中脂碱的来源。方法利用电喷雾离子阱质谱分析比较生附子、四逆汤、煎煮后生附子药渣、生附子与半夏共煎液中的生物碱。结果在四逆汤中检测到少量脂碱,在生附子与半夏共煎液中未检测到脂碱,脂碱成为煎煮过生附子中的主要生物碱。结论脂碱在加热条件下也不溶于水,在四逆汤中检测到的脂碱来源于双酯型生物碱的酯交换反应。
|
| 关 键 词： | 四逆汤 附子 电喷雾串联质谱 酯交换反应 |
Lipo-alkaloids in Sini Decoction stemmed from ester-exchange reactions |
| |
| WANG Yong,SONG Feng-rui,LIU Zhi-qiang,LIU Shu-ying.Lipo-alkaloids in Sini Decoction stemmed from ester-exchange reactions[J].Researches in Medical Education,2006(1):51-54. |
| |
| Authors: | WANG Yong SONG Feng-rui LIU Zhi-qiang LIU Shu-ying |
| |
| Institution: | 1. Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Science, Shenzhen University, Shenzhen 518060, China; 2. The New Drug Laboratory of Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130024, China |
| |
| Abstract: | Objective To study the solubility of lipo-alkaloids from prepared aconite root(Radix Aconiti Lateralis Preparata) and identify the sources of lipo-alkaloids in Sini Decoction.Methods The electrospray ionization mass spectrometry was employed to analyze the alkaloids in crude aconite roots,Sini Decoction,the gruffs of concocted aconite roots and the decoction of prepared aconite root and pinellia tuber(Rhizoma Pinellae).Results Lipo-alkaloids were observed in Sini Decoction,however,no lipo-(alkaloids) were found in the decoction of aconite roots with pinellia tuber.Lipo-alkaloids were the dominant components in the gruffs of concocted aconite roots.Conclusion Lipo-alkaloids are barely soluble in boiling water.The alkaloids existed in the Sini Decoction stem from the ester-exchange reactions of diester-diterpenoid alkaloids and fatty acid in the boiling water. |
| |
| Keywords: | Sini Decoction prepared aconite root(Radix Aconiti Lateralis Preparata) ESI-MS~n ester-exchange reaction |
|
| 点击此处可从《医学教育探索》浏览原始摘要信息 |
| 点击此处可从《医学教育探索》下载免费的PDF全文 |
|
