Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong |
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| Authors: | Kam Kai Man Kam Shirley Sin Yee Cheung Danny Tze Leung Tung Viola Wai Na Au Wai Fun Cheung May May |
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| Affiliation: | Sexually Transmitted Diseases Laboratory, Public Health Laboratory Centre, Pathology Service, Department of Health, Kowloon, Hong Kong, China. kmkam@dh-gov.hk |
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| Abstract: | In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity. |
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