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| 慢性间断性缺氧对帕金森病模型小鼠认知功能的影响 | |
| 引用本文： | 刘海林,徐江涛,宋永斌,杨俊,许永华,余伍忠,李景春,张子彦.慢性间断性缺氧对帕金森病模型小鼠认知功能的影响[J].新医学,2011,42(6):382-385. |
| 作者姓名： | 刘海林 徐江涛 宋永斌 杨俊 许永华 余伍忠 李景春 张子彦 |
| 作者单位： | 1. 石河子大学医学院,832000 2. 兰州军区乌鲁木齐总医院神经内科,830000 3. 兰州军区乌鲁木齐总医院动物科,830000 4. 兰州军区乌鲁木齐总医院临床医学研究所,830000 |
| 基金项目： | 兰州军区医药卫生科研项目 |
| 摘 要： | 目的：探讨慢性间断性缺氧（CIH）对帕金森病模型小鼠认知功能的影响。方法：44只雄性6周龄C57BL/6小鼠,随机分为百草枯组、CIH组、百草枯加CIH组和对照组。用缺氧-复氧循环装置模拟CIH过程,通过腹腔注射百草枯诱导制备帕金森病模型小鼠。使用Y型-电迷宫和跳台实验评价小鼠学习记忆能力;化学比色法测定小鼠海马乙酰胆碱含量和乙酰胆碱酯酶活性。结果：3个实验组的学习记忆成绩、乙酰胆碱含量和乙酰胆碱酯酶活性均明显低于对照组（P均〈0.01）,其中百草枯加CIH组明显低于百草枯组与CIH组（P均〈0.05）,百草枯组与CIH组比较差异无统计学意义（P均〉0.05）。结论：CIH加重了百草枯所致帕金森病模型小鼠认知功能下降程度,可能与海马Ach含量下降和Ach E活性降低有关。 |
| 关 键 词： | 帕金森病 慢性间断性缺氧 认知功能 乙酰胆碱 |
Effect of chronic intermittent hypoxia on the cognitive function of mouse model for Parkinson's disease |
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| LIU Hai-lin,XU Jiang-tao,SONG Yong-bin,YANG Jun,XU Yong-hua,YU Wu-zhong,LI Jing-chun,ZHANG Zi-yan.Effect of chronic intermittent hypoxia on the cognitive function of mouse model for Parkinson's disease[J].New Chinese Medicine,2011,42(6):382-385. | |
| Authors: | LIU Hai-lin XU Jiang-tao SONG Yong-bin YANG Jun XU Yong-hua YU Wu-zhong LI Jing-chun ZHANG Zi-yan |
| Institution: | LIU Hai-lin1,XU Jiang-tao2,SONG Yong-bin2,YANG Jun2,XU Yong-hua3,YU Wu-zhong4,LI Jing-chun2,ZHANG Zi-yan2. 1 Medical College of Shihezi University,Shihezi 832000,China,2 Department of Neurology,Urumqi General Hospital,Lanzhou Command,PLA,Urumqi 830000,3 Department of Animal Experiment,4 Department of Clinical Research |
| Abstract: | Objective: To investigate the effect of chronic intermittent hypoxia on cognitive function in the mouse model of Parkinson's disease.Methods: Forty-four six-week-old male C57BL/6 mice were randomly divided into Paraquat(PQ) group,chronic intermittent hypoxia(CIH) group,PQ + CIH group and control group.Hypoxia-reoxygen device simulates the process of CIH.Meanwhile,intraperitoneal injection of PQ induced the mouse model of Parkinson's disease.Learning and memory function were evaluated by Y-type maze and step... |
| Keywords: | Parkinson's disease Chronic intermittent hypoxia Cognition Acetylcholine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |