| 膀胱出口梗阻所致逼尿肌尿动力学及超微结构的变化 |
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| 引用本文： | 周逢海,王养民,景德善,宋波,金锡御. 膀胱出口梗阻所致逼尿肌尿动力学及超微结构的变化[J]. 西北国防医学杂志, 2005, 26(6): 404-406,F0002 |
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| 作者姓名： | 周逢海 王养民 景德善 宋波 金锡御 |
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| 作者单位： | 1. 兰州军区兰州总医院泌尿外科,甘肃,兰州,730050
2. 第三军医大学西南医院泌尿外科 |
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| 基金项目： | 国家自然科学基金资助项目（30271304） |
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| 摘 要： | 目的：观察膀胱出口梗阻（BOO）后逼尿肌尿动力学及超微结构的改变。方法：通过改良法，建立BOO后引起逼尿肌不稳定（DI）的动物模型，根据尿动力学检查结果分为DI组和正常对照组，在了解逼尿肌功能变化基础上，利用透射电镜观察逼尿肌细胞的超微结构变化。结果：DI组逼尿肌细胞间连接以缝隙连接（GJ）为主要方式，正常对照组细胞以中间连接（IJ）为主。结论：BOO后膀胱逼尿肌功能改变与细胞超微结构改变有关，且GJ通道在DI发生中有重要作用。
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| 关 键 词： | 膀胱出口梗阻 逼尿肌不稳定 细胞间连接 |
| 文章编号： | 1007-8622（2005）06-0404-03 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-09-12 |
Dynamics and ultrastructural changes of bladder detrusor following partial outlet obstruction |
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| ZHOU Feng - hai, WANG Yang - min, JING De -shan,et al.. Dynamics and ultrastructural changes of bladder detrusor following partial outlet obstruction[J]. Medical Journal of National Defending Forces in Northwest China, 2005, 26(6): 404-406,F0002 |
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| Authors: | ZHOU Feng - hai WANG Yang - min JING De -shan et al. |
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| Affiliation: | ZHOU Feng - hai, WANG Yang - min, JING De -shan, et al. |
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| Abstract: | Objective:To observe the dynamics and the ultrastructural changes of bladder detrusor following bladder outlet obstruction.Methods: Proximal urethra were partially ligated to produce the rat bladder outlet obstruction(BOO) models.Intravesical pressure was measured 6 weeks later.According to the dynamic result,fifty rats were divided into detrusor instability(DI) group and control group.Transmission electron microscopy was used to study the ultrastructure in the samples of detrusor.Results: There were a large number of gap junction(GJ) in DI group,and intermediate junction(IJ) in control group.Conclusion:The functional changes of bladder detrusor following BOO is related with the ultrastructure,an increase of GJ passage between detrusor cells might play an(important) role in the pathogenesis of detrusor instability. |
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| Keywords: | Bladder outlet obstruction Detrusor instability Cell - cell junction |
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