41例复发转移恶性黑色素瘤治疗结果分析

本文共选择在外院经１次以上治疗后又转移复发的恶性黑色瘤４１例。全组中位生存时间２０．２个月，２年生存率５３．６％，５年生存率４．８％。手术结合瘤苗治疗２７例，单纯手术治疗１４例，前者中位生存时间明显长于后者，３４．３个月和１７．５个月（Ｐ＝０．０００１）。全组完全数据３３例，截尾数据８例（８０．４８％，１９．５％）。肿瘤患者的年龄、性别、大小及肿瘤部位在２组中的分布无差别（Ｐ＝０．９９，Ｐ＝０．１９，Ｐ＝０．５７）。在生存分布上下列诸因素间无差异：年龄Ｐ＝０．４３，性别Ｐ＝０．４，部位Ｐ＝０．７２。结果分析显示恶性黑色素瘤患者生存时间与肿瘤的大小及是否使用瘤苗有关。

Analysis of the Results of Treatment of 41 Patients with Retaliative and/or Relapsed Malignant Melanoma

Forty one cases of malignant melanoma were found to have metastasis and relapse afterthe operations performed in other hospitals.Their mean survival period was 20. 2 monthswith 53. 6% having a 2-year survival rate,and 4.8% having a 5-year survival rate. 27 cases(group1) were treated surgically with vaccinantion of autologous tumor cells; 14 cases(group 2) underwent surgery alone.Group 1 had much longer mean survival period thangroup 2(34.3 and 17. 5 month).The uncensored were 33 cases and the censored were 8 cases(80.48 %,19. 5%). Between these two groups, no significant difference was seen in their gae,sex and the size and site of tumor (P=0.99,P=0.82,P=0. 19,P=0.57). In survival distribution,no significant difference was noted in the following aspects:in age P=0.43,in sex P=0.47 and in site of lesion P=0.72.The analysis implies that the survival period of patientswith malignant melanoma was associated with the vaccinantion of autologous tumor cells.