| 徐州地区汉族人及慢性乙型肝炎HLA-A基因多态性的研究 |
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| 引用本文： | 戴玮玮,陈明,汪莉萍,孙海丰,傅涓涓,李秀华. 徐州地区汉族人及慢性乙型肝炎HLA-A基因多态性的研究[J]. 临床肝胆病杂志, 2007, 23(2): 100-102 |
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| 作者姓名： | 戴玮玮 陈明 汪莉萍 孙海丰 傅涓涓 李秀华 |
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| 作者单位： | 南京市第二医院;徐州医学院附属医院感染病科,江苏,221002;丰县人民医院感染病科,江苏,丰县,221700 |
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| 基金项目： | 江苏省科委社会发展基金资助（BS2004014） |
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| 摘 要： | 探讨慢性乙型肝炎与HLA-A位点的等位基因多态性.用PCR-SSP方法对徐州地区汉族正常组和慢性乙型肝炎组的HLA-A基因多态性进行分析.HLA-A＊0201-17出现的频率在慢性乙型肝炎组为45.57%,高于正常组的29.69%,P=0.002＜0.05,RR=1.983,（95%CI：1.227-3.080）,具有统计学意义.HLA-A＊0201-17与慢性乙型肝炎较高的相关性,可能为易感基因.
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| 关 键 词： | 乙型肝炎 疾病易感性 人类白细胞抗原 序列特异性引物聚合酶链反应 |
| 文章编号： | 1001-5256（2007）02-0100-03 |
| 收稿时间： | 2006-03-02 |
| 修稿时间： | 2006-03-23 |
The relationship between HLA -A alleles polymorphism and susceptibility to HBV in the Han nationality in Xuzhou |
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| DAI Wei - wei, CHEN Ming, WANG Li - ping,et al.. The relationship between HLA -A alleles polymorphism and susceptibility to HBV in the Han nationality in Xuzhou[J]. Chinese Journal of Clinical Hepatology, 2007, 23(2): 100-102 |
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| Authors: | DAI Wei - wei CHEN Ming WANG Li - ping et al. |
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| Affiliation: | The Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China |
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| Abstract: | To investigate the relationship between HLA-A alleles polymorphism and susceptibility to HBV in the Han nationality in Xuzhou.Typing HLA-A genotype was performed by using PCR-SSP(polymerase chain reaction-sequence specific primers technique) in seventy-nine patients with hepatitis B and ninty-six healthy people in Xuzhou of China.The frequency of HLA-A*0201-0217 allele was 45.57% in patient group,which was higher than that(29.69%) of the normal healthy people(x2=9.394,P<0.05,RR=1.983,95%CI:1.227~3.080).The susceptibility to chronic hepatitis B might be strongly associated with HLA-A*0201-0217 allele of Chinese patients in Xuzhou. |
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| Keywords: | hepatitis B susceptibility human leukocyte antigen PCR - SSP |
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