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Relationship between clinical examination, Quality of Life, disability and depression in CMT patients: Italian Multicenter study |
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| Authors: | L Padua I Aprile T Cavallaro I Commodari D Pareyson A Quattrone N Rizzuto G Vita P Tonali A Schenone |
| Institution: | 1. Institute of Neurology, Università Cattolica, Roma, Italy 2. Fondazione Pro Juventute Don Carlo Gnocchi, Roma, Italy 3. Department of Neurological and Visual Sciences Section of Clinical Neurology, University of Verona, Verona, Italy 4. Department of Neurosciences, Università degli Studi di Catania, Catania, Italy 5. Istituto Nazionale Neurologico “C. Besta”, Milano, Italy 6. Azienda O.U. Policlinico di Catanzaro, Università di Catanzaro, Catanzaro, Italy 7. Policlinico GB Rossi, Università di Verona, Verona, Italy 8. Department of Neuroscience, Psychiatry and Anaesthesiology, Azienda O.U. Policlinico di Messina, Messina, Italy 9. Department of Neurological and Vision Sciences, Genova, Italy |
| Abstract: | Objective To assess which are the clinical examination tests that are more related to quality of life (QoL), depression, and disability in CMT patients. Design Large prospective multicenter study through the use of validated clinical, disability, and QoL measurements. Correlations between clinical pattern and disability/QoL and depression were studied. Setting Departments of Neurology. Patients and participants 211 CMT patients (60% females, mean age 42.5 years). Interventions None. Measurements and results Sensory function was related to both mental and physical aspects of patient’s QoL. Ability to walk on toes and heels was related to physical aspects of QoL/disability but also to bodily pain. Strength of forearm/hand intrinsic muscles was related to disability and physical aspects of QoL. Conclusions Some clinical tests may be better outcome measures than others because they are related to aspects of life highly relevant to the patients. This information may be useful in clinical practice and in clinical trials to infer the patient’s QoL. |
| Keywords: | Quality of life Disability Charcot-Marie-Tooth Clinical examination Outcome measures |
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