Effects of cimetidine and atropine sulfate on gastric secretion and healing of gastric and duodenal ulcers in rats. |
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| Authors: | S Okabe K Takeuchi T Murata K Takagi |
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| Institution: | Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, UNiversity of Tokyo, Hongo, Bunkyo, Tokyo, Japan |
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| Abstract: | Cimetidine, a new histamine H2-receptor antagonist (50 or 100 mg/kg) and atropine sulfate (15 mg/kg) given intraduodenally, markedly inhibited gastric secretion in pylorus-ligated rats. Cimetidine (100 or 200 mg/kg/day) given for 10 or 12 consecutive days orally in two divided doses, significantly promoted the healing rate of both gastric and duodenal ulcers induced in rats. Atropine (30 mg/kg/day) also significantly accelerated the healing of duodenal ulcers but failed to affect gastric ulcers. |
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| Keywords: | Cimitidine Atropine Gatric secretion Gastric ulcer Duodenal ulcer |
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