| 染料木黄酮对小鼠子宫内膜癌c-fos、cj-un mRNA表达的影响 |
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| 引用本文： | 尹香花,李虹娇,李俊霞. 染料木黄酮对小鼠子宫内膜癌c-fos、cj-un mRNA表达的影响[J]. 实用临床医药杂志, 2009, 13(23): 22-25 |
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| 作者姓名： | 尹香花 李虹娇 李俊霞 |
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| 作者单位： | 1. 扬州大学临床医学院,妇产科,江苏,扬州,225001
2. 吉林延边大学附属医院,妇产科,吉林,延边,132000 |
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| 摘 要： | 目的探讨染料木黄酮对雌二醇-17β(E2)所诱发的小鼠子宫内膜癌c-fos、c-jun mRNA表达的影响。方法利用免疫组化方法和定量RT-PCR法检测小鼠子宫内膜癌细胞c-fos、c-jun mRNA的表达量。结果E2单独投与群c-fos、c-jun mR-NA表达增强,与E2单独投与群比较,E2和染料木黄酮联合投与群明显抑制E2刺激所诱发的c-jun表达增强。c-fos mRNA表达有减少趋势。结论E2皮下注射的雌性ICR小鼠给予染料木黄酮后c-fos、c-jun mRNA表达减少,对子宫内膜癌的预防有一定的意义。
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| 关 键 词： | 染料木黄酮 c-fos、c-jun基因 小鼠子宫内膜癌 |
Effects of Genistein on the expression of c-fos, c-jun mRNA in mice endometrial cancer |
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| YIN Xiang-hua,LI Hong-jiao,LI Jun-xia. Effects of Genistein on the expression of c-fos, c-jun mRNA in mice endometrial cancer[J]. Journal of Clinical Medicine in Practice, 2009, 13(23): 22-25 |
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| Authors: | YIN Xiang-hua LI Hong-jiao LI Jun-xia |
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| Abstract: | Objective To study the effect of Genistein on the expression of c-fos,c-jun mRNA in Estrogin(E2)-induced endometrial cancer in ICR mice and study it′s preventive value for tumor.Mothods Immunohistochemical method and real time RT-PCR technique to detect the expression level of c-fos,c-jun mRNA in the endomtrial cancer cell in ICR mice.Results When Estrogin(E2) was given alone,the expression of c-fos,c-jun mRNA increased significantly.While Estrogin(E2) and Genistein were given together,Genistein significantly decreased the expression of c-fun which was induced by Estrogin(E2).The expression of c-fos also had a decreasing dendency.Conclusion When female ICR mice with s.c injection of Estrogin(E2) were given Genistein,the expression of c-fos,c-jun mRNA decreased.It had certain significance for the prevention of endometrial cancer. |
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| Keywords: | genistein c-fos 、c-jun gene endometrial cancer |
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