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Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features
Authors:Yuko Omori  Yusuke Ono  Mishie Tanino  Hidenori Karasaki  Hiroshi Yamaguchi  Toru Furukawa  Katsuro Enomoto  Jun Ueda  Atsuko Sumi  Jin Katayama  Miho Muraki  Kenzui Taniue  Kuniyuki Takahashi  Yoshiyasu Ambo  Toshiya Shinohara  Hiroshi Nishihara  Junpei Sasajima  Hiroyuki Maguchi  Shinya Tanaka
Affiliation:1. Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan;2. Department of Pathology, Teine-Keijinkai Hospital, Sapporo, Japan;3. Institute of Biomedical Research, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan;4. Department of Medicine, Asahikawa Medical University, Asahikawa, Japan;5. Division of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan;6. Department of Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan;7. Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan;8. Diagnostic Partnering, Clinical Sequencing Division, Thermo Fisher Scientific, Tokyo, Japan;9. Genomedia Inc., Tokyo, Japan;10. Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan;11. Department of Surgery, Teine-Keijinkai Hospital, Sapporo, Japan;12. Cancer Center, Keio University Hospital, Tokyo, Japan
Abstract:
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  • Keywords:Pancreas  Risk Prediction  Tumorigenesis  Progression Model  FFPE  formalin-fixed paraffin embedded  HG  high-grade  IPMN  intraductal papillary mucinous neoplasm  LG  low-grade  MNL  microscopic neoplastic lesions  PanIN  pancreatic intraepithelial neoplasia  PCR  polymerase chain reaction  PDA  pancreatic ductal adenocarcinoma  TSG  tumor suppressor gene
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