| 乙酰胆碱与电针对脑内5羟色胺代谢的影响 |
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| 引用本文： | 关新民,王才源,刘晓春,张育文,曾宪英,梁勋厂,李玲琍. 乙酰胆碱与电针对脑内5羟色胺代谢的影响[J]. 针刺研究, 1988, 0(4) |
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| 作者姓名： | 关新民 王才源 刘晓春 张育文 曾宪英 梁勋厂 李玲琍 |
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| 作者单位： | 同济医科大学针刺镇痛原理研究室，同济医科大学针刺镇痛原理研究室，同济医科大学针刺镇痛原理研究室，同济医科大学针刺镇痛原理研究室，同济医科大学针刺镇痛原理研究室，同济医科大学针刺镇痛原理研究室，同济医科大学针刺镇痛原理研究室 |
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| 摘 要： | <正> 为了研究针刺镇痛过程中 ACh 和单胺类递质之间的关系,本文观察了电针镇痛过程中 ACh、5-HT、5-HIAA,含量的变化,又利用胆碱酯酶抑制剂(毒扁豆碱)和 ACh合成阻断剂(密胆碱)分别升高或降低脑内ACh 的方法观察电针对5-HT 代谢的影响。发现:针刺镇痛过程中5-HT 的代谢变化与ACh 有一定的关系。
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THE INFLUENCE OF ACH ON THE METABOLISM OF 5-HT IN THE BRAIN DURING ACUPUNCTURE ANALGESIA |
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| Abstract: | The main purpose of the present paper is to investigate the influence of the ACh on the metabolism of 5-HT in the brain of rat during acupuncture analgesia(EA).The results find that;1)the pain threshold and the contents of ACh,5-HT and 5-HIAA in brain of rat were both significantly enhanced at simultaneously by EA.2)EA could further increase or decrease the contents ofACh,5-HT and HIAA in the brain of rats which had been treated by eserine or hemicholine (HC-3).The regression analysis indicate that the relationship correlation between the percentage of increase or decrease of ACh and 5-HT,5-HIAA in rat brain by eserine or HC-3 during EA present linear positive correlation.These results suggeste that ACh could influence the metablism of 5-HT under the action of EA.Thus it is considered that the role of ACh in EA is probably refered to its effect on the metabolism of 5-HT in certain extent, |
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