中医体质分类与肺癌预后因素相关性分析

目的:探讨肺癌各项预后因素在中医体质类型中的分布差异,分析中医体质与肺癌预后因素的相关性。方法:选取2010年3月—2011年3月于广东省中医院肿瘤科住院的符合纳入标准的临床肺癌患者254例,采用标准化的9种中医体质分类量表对其进行肺癌中医体质问卷调查。结果:患者的体质类型分布主要以平和质、气虚质、阳虚质和阴虚质为主,这4种体质约占3/4(72.9%),其次是气郁质,占10.2%。病理体质类型主要以气虚质为主,所占比例32.3%。对各体质与临床肺癌预后因素进行多因素logistic回归分析,结果显示:(1)平和质、气虚质、阳虚质、阴虚质及血瘀质这5种体质类型表达与中医治疗呈负相关(P=0.000),差异有统计学意义。(2)阳虚质表达与临床分期呈正相关(P<0.05),差异有统计学意义。(3)阴虚质表达与年龄呈正相关(P<0.05),差异有统计学意义;组织分型、手术治疗以及放疗或化疗与阴虚质表达无相关。结论:肺癌患者的偏颇体质主要以气虚质为主,中医治疗是与体质类型相关最多的因素,肺癌患者由于中医治疗的介入可能影响其体质的改变,而气虚质和阴虚质与中医治疗最密切。

Distribution of Traditional Chinese Medicine Constitution and Prognosis Analysis in Lung Cancer

Objective:To investigate the distribution of prognostic factors in Chinese medicine constitution and analyze the relationship between Chinese medicine constitution and prognostic factors among cases with lung cancer.Method:Standardized classification measurement questionnaire of nine constitutions in Chinese medicine,was used to investigate the Chinese medicine constitution of 254 lung cancer patients,who were selected from Oncology of Guangdong Provincial Hospital and consisitent with the inclusion criteria from March 2010 to March 2011.Results:The constitution in Chinese medicine was as follows:Gentleness type,Qi-deficiency type,Yang-deficiency type and Yin-deficiency type,which accounted for about fourths(72.9%),followed by Qi-depression,accounting for 10.2%.The main type of pathologicalconstitution was Qi-depression type,accounting for 32.3%.On the physical and clinical prognostic factors of lung cancer A multivariate logistic regression analysis showed that:(1)Gentleness,Qi-deficiency,Yang-deficiency,Yin-deficiency and Blood-stasis type of Chinese medicine constitution and Chinese medicine treatment were negatively correlated(P=0.000).(2)Yang-deficiency tape was positively correlated with the clinical stage(P<0.05).(3) Yin-deficiency tape was positively correlated with age(P<0.05).The differences above were all statistically significant.Histological type,surgical treatment and radiotherapy or chemotherapy,had no correlation with the Yin-deficiency.Conclusions:Patients with lung cancer were mainly Qi-deficiency type.Chinese medicine treatment was associated with the Chinese medicine constitution.Because the involvement of Chinese medicine might affect patients’ physical changes,while Qi-deficiency and Yin-deficiency type have the closest relation with Chinese medicine treatment.