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复方苦参注射液联合顺铂灌注治疗恶性胸腔积液的临床观察
引用本文:朱明珍,蒋华,朱志霞,徐海燕.复方苦参注射液联合顺铂灌注治疗恶性胸腔积液的临床观察[J].天津药学,2013(6):30-32.
作者姓名:朱明珍  蒋华  朱志霞  徐海燕
作者单位:连云港市第二人民医院海州院区,连云港222023
摘    要:目的:控制恶性胸腔积液,缓解临床症状,提高患者生活质量.方法:确诊为恶性胸腔积液的患者56例,随机分为治疗组(28例)和对照组(28例),两组胸腔内均注入顺铂60 mg溶于氯化钠注射液40 ml中,治疗组同时加复方苦参注射液20 ml胸腔注入,每周1次,连用2次为1个疗程.观察两组的胸水消失情况、KPS评分变化及副反应情况.结果:治疗组完全缓解9例,部分缓解14例,无效5例;对照组,依次为6、13、9例.两组总有效率及治疗前后KPS评分及副反应比较,差异均有统计学意义(P〈0.05).结论:复方苦参注射液联合顺铂胸腔内灌注治疗恶性胸腔积液疗效肯定,副反应轻.

关 键 词:复方苦参注射液  顺铂  恶性胸腔积液

Clinical observation of perfusion with compound kusheng injection plus cisplatin for malignant pleural fluid
Zhu Mingzhen,Jiang Hua,Zhu Zhixia,Xu Haiyan.Clinical observation of perfusion with compound kusheng injection plus cisplatin for malignant pleural fluid[J].Tianjin Pharmacy,2013(6):30-32.
Authors:Zhu Mingzhen  Jiang Hua  Zhu Zhixia  Xu Haiyan
Institution:( The Second People's Hospital of LianYungang, LianYungang,222023 )
Abstract:Objective :To Control the pleural effusion,relieve the clinical symptoms and improve the quality of life. Methods:A to- tal of 56 cases who had been diagnosed as having malignant pleural effusion were randomly assigned to receive compound Kusheng injection plus cisplatin ( The treatment group, n = 28 ) or cisplatin alone ( the control group) following the chest tube insertion. Two groups of the patients were given 60 mg cisplatin soluble in 40 ml physiological saline by thoracic perfusio, compound Kuhseng in- jection 20 ml was also given in the treatment group, 1 times per week, twice for a course of treatment. We observed two groups'situa- tion about pleural effusion disappeared, KPS score changes and the adverse event. Results: The treatment group has CR 9case, PR 14case, N C 5cases, the control group has 6,13,9 respectively, There were significant differences between two groups about the total effective rate, KPS score and the adverse event ( P 〈 0.05 ). Conclusion. Compound kusheng injection plus cisplatin pleural perfu- sion has determinate effect, with little adverse effects on malignant pleural effusion .
Keywords:compound Kuhseng injection  cisplatin  malignant pleural effusion
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