三维适行放疗同期多西紫杉醇和顺铂化疗治疗中晚期食管癌的临床观察

目的 探讨三维适行放疗同期多西紫杉醇和顺铂化疗治疗中晚期食管癌的疗效及毒副反应.方法 68例中晚期食管癌患者随机分为2组,观察组35例接受三维适形放疗同期联合多西紫杉醇和顺铂化疗,对照组33例患者仅接受三维适形放疗.结果 观察组总有效率为82.9%,对照组为69.7%（P〈0.05）.观察组1、2 a生存率分别为68.6%,40.0%,对照组分别为60.6%,30.3%,2组生存率曲线差异有统计学意义（P〈0.05）.结论 三维适行放疗同期多西紫杉醇和顺铂化疗能提高中晚期食管癌的近期疗效,延长生存期,且毒副反应可耐受.

Three-dimensional Conformal Radiotherapy Combined with Concurrent Docetaxel plus Cisplatin Chemotherapy for Advanced Esophageal Carcinoma

Objective To explore the efficacy and toxicities of three-dimensional conformal radiotherapy combined with concurrent doeetaxel plus cisplatin chemotherapy for advanced esophageal carcinoma. Methods Sixty- eight patients with advanced esophageal carcinoma were divided into the two groups, 35 patients of the observation group received three-dimensional conformal radiotherapy and concurrent docetaxel plus cisplatin chemotherapy, 33 patients of the control group received three-dimensional conformal radiotherapy. Results The total response rate was 93.3% of the observation group, and was 83.3% of the control group （ P 〈 0.05 ）. The 1- ,2-year survival rates were 68.6% and 40.0% of the observation group ,and were 60.6% and 30.3% ,the differences of survival curves were statistically significant （ P 〈 O. 05 ）. Conclusion Three-dimensional conformal radiotherapy combined with concurrent docetaxel plus cisplatin can improve short-term efficiency and prolong the survival time of patients with advanced esophageal carcinoma, and the toxicities can be tolerated.