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| Vaccination with a Recombinant Chicken FGFR-1 Bypasses Immunological Tolerance against Self-FGFR-1 in Mice | |
| 引用本文： | 郑少江,黄凤迎,郑少萍,王伟,尹辉,吴人亮. Vaccination with a Recombinant Chicken FGFR-1 Bypasses Immunological Tolerance against Self-FGFR-1 in Mice[J]. 华中科技大学学报(医学英德文版), 2006, 26(4): 389-391. DOI: 10.1007/s11596-006-0401-2 |
| 作者姓名： | 郑少江 黄凤迎 郑少萍 王伟 尹辉 吴人亮 |
| 作者单位： | Department of Pathology School of Basic Science，Tongji Medical College，Huazhong University Science and Technology Wuhan 430030，China，Department of Pathology，Hainan Medical College，Haikou 571101，China，Hainan Province Key Laboratory of Tropical Medicine，Hainan Medical College，Haikou 571101，China，Department of Physiology，Hainan Medical College，Haikou 571101，China，Department of Pathology，School of Basic Science，Tongji Medical College，Huazhong University Science and Technology Wuhan 430030，China，Department of Pathology，School of Basic Science，Tongji Medical College，Huazhong University Science and Technology Wuhan 430030，China，Department of Pathology，School of Basic Science，Tongji Medical College，Huazhong University Science and Technology Wuhan 430030，China |
| 基金项目： | This work was supported by a 2003 grant of Hainan Pro-vincial Natural Sciences Foundation (No.30321) |
| 摘 要： | It has been generally believed that that the growth and metastasis of solid tumors depend on tumor angiogenesis, the generation of new blood vessels. At present, basic fibroblast growth factor (bFGF) has been shown to be one of the most important angiogenic growth factors for tumor angiogenesis. bFGF serves its biological functions through interaction with its high-affinity receptor, fibro- blast growth factor receptor-1(FGFR-1)[1–3]. FGFR-1 is a member of the receptor tyrosine kinase co… |
| 关 键 词： | 疫苗接种 重组细胞 免疫功能 Self-FGFR-1 小鼠 |
| 收稿时间： | 2006-02-15 |
Vaccination with a recombinant chicken FGFR-1 bypasses immunological tolerance against self-FGFR-1 in mice |
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| Shaojiang Zheng,Fengying Huang,Shaoping Zheng,Wei Wang,Hui Yin,Renliang Wu. Vaccination with a recombinant chicken FGFR-1 bypasses immunological tolerance against self-FGFR-1 in mice[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(4): 389-391. DOI: 10.1007/s11596-006-0401-2 | |
| Authors: | Shaojiang Zheng Fengying Huang Shaoping Zheng Wei Wang Hui Yin Renliang Wu |
| Affiliation: | 1. Department of Pathology, School of Basic Science, Tongji Medical College, Huazhong University Science and Technology, Wuhan 430030, China;Department of Pathology, Hainan Medical College, Haikou 571101, China 2. Hainan Province Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou 5 71101, China 3. Department of Physiology, Hainan Medical College, Haikou 571101, China 4. Department of Pathology, School of Basic Science, Tongji Medical College, Huazhong University Science and Technology, Wuhan 430030, China |
| Abstract: | The possibility that a recombinant protein vaccine based on xenogeneic homologous FGFR-1 of chicken induces production of autoantibodies against self-FGFR-1 in BALB/c mice was examined by using ELISA, Western blot analysis and ELISPOT assay respectively. Autoantibodies against mouse FGFR-1 were identified by Western blot analysis and ELISA. Compared with the two control groups, the number of APBCs, which were detected by ELISPOT assay, was significantly in- creased in the spleens of mice immunized with cFR1 (P<0.05). IgG1 and IgG2b, which were de- tected by ELISA, were the major subclasses and were substantially increased in response to chicken FGFR-1 when compared with control group. The recombinant chicken FGFR-1 protein used as a vaccine can induce autoantibodies against self-FGFR-1 in mice and provide a basis for the active immunotherapy of tumor angiogenesis. |
| Keywords: | fibroblast growth factor receptor-1 tumor angiogenesis protein vaccine active im- munotherapy |
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