肝功能不全患者的药学监护研究

目的 开展对肝功能不全患者的药学监护研究.方法 将新入院患者生化指标划分肝功能不全的严重程度分级,将筛选的肝功能不全患者随机分成两组,对干预组进行实施药学监护,观察实施药学监护后两组药物的不良反应发生率、住院天数、住院费用、患者满意度等.结果 干预组实施药学监护干预后,患者平均住院天数,平均住院费用,药费比例,使用抗生素比例、抗生素占总药费的比例、使用注射液比例、注射液占总药费的比例,药物不良反应发生率较对照组均显著降低（p＜0.01）;基本药物使用比例,患者满意度比对照组明显增高（p＜0.01）.结论 对肝功能不全患者实施药学监护和干预,用药的安全性、有效性和经济性.

STUDY ON PHARMACEUTICAL CARE IN PATIENTS WITH HEPATIC INSUFFICIENCY

Objective Study on pharmaceutical care of the patients with hepatic insufficiency. Methods According to biochemical index, new patients with hepatic insufficiency were classified. The patients were randomly divided into two groups：intervention group and control group. In intervention group, patient received pharmaceutical care. Then comprehensive incidence of adverse reactions, hospitalization days, hospitalization expenses and patient satisfaction before and after pharmaceutical care were observed. Results After pharmaceutical care, the average hos- pital stay, average hospitalization expenses, drug fee, antibiotics use ratio, injection use ratio and incidence of ad- verse reactions decreased significantly （p 〈 0.01 ）. Essential Drugs use ratio and patient satisfaction were significantly higher than the control group （p 〈 0.01 ）. Conclusion Implementation of pharmaceutical care can make the use of drut~s more safely, effectively and economically.