| 重编程诱导多功能干细胞的研究进展 |
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| 引用本文： | 郭晓令,刘庆,王婵,郭永龙,余榕捷,陈建苏.重编程诱导多功能干细胞的研究进展[J].中国病理生理杂志,2014,30(7):1218-1227. |
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| 作者姓名： | 郭晓令 刘庆 王婵 郭永龙 余榕捷 陈建苏 |
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| 作者单位： | 暨南大学 1再生医学教育部重点实验室， 2医学院眼科研究所，3附属第一临床学院眼科， 4生命科学技术学院细胞生物学系，广东 广州 510632 |
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| 基金项目： | 国家自然科学基金资助项目 (No. 81371689)；广东省自然科学基金资助项目 (No. S2013010013391) |
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| 摘 要： |
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| 关 键 词： | 诱导多能性干细胞 安全性 有效性 |
| 收稿时间： | 2013-12-03 |
Research progress in reprogramming induced pluripotent stem cells |
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| GUO Xiao-ling,LIU Qing,WANG Chan,GUO Yong-long,YU Rong-jie,CHEN Jian-su.Research progress in reprogramming induced pluripotent stem cells[J].Chinese Journal of Pathophysiology,2014,30(7):1218-1227. |
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| Authors: | GUO Xiao-ling LIU Qing WANG Chan GUO Yong-long YU Rong-jie CHEN Jian-su |
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| Institution: | 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Eye Institute, School of Medicine, 3Department of Ophthalmology, The First College of Clinical Medicine, 4Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. |
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| Abstract: | Induced pluripotent stem cells (iPSCs) have been first induced from mouse fibroblasts since 2006, and the research on iPSCs has made great progress in the following years. iPS cell lines were established from different somatic cells through DNA, RNA, protein, and small molecule compounds and various methods of transduction, making the induction of iPSCs more secure and effective, and more attractive prospect of clinical application. In this review, different somatic cell reprogramming, different levels of reprogramming, different transduction pathways, and prospect of application are discussed. |
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| Keywords: | Induced pluripotent stem cells Safety Efficiency |
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