| 去泛素化酶BRCC36功能的研究进展 |
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| 引用本文： | 李如君,龚开政,张振刚. 去泛素化酶BRCC36功能的研究进展[J]. 中国病理生理杂志, 2014, 30(9): 1713-1716. DOI: 10.3969/j.issn.1000-4718.2014.09.030 |
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| 作者姓名： | 李如君 龚开政 张振刚 |
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| 作者单位： | 扬州大学第二临床医学院心血管内科,江苏 扬州 225001 |
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| 基金项目： | 国家自然科学基金资助项目（No.81270197；No.81270198）;江苏省第四期科教兴卫工程项目基金资助项目（No.RC2011045） |
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| 摘 要： | BRCC36蛋白是一种可特异性水解K63位点聚泛素化链的蛋白质，它广泛存在于多种真核生物体内，可识别多种不同的底物蛋白，参与多种细胞病理生理过程。与DNA损伤修复、细胞信号的转导、细胞周期控制具有密切联系，在肿瘤发生、血管生成、心脏抗损伤过程中发挥重要作用。本文就BRCC36蛋白的最新研究情况做一综述，为临床研究多种疾病的新型治疗靶点提供必要的信息。
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| 关 键 词： | BRCC36蛋白 泛素化 DNA损伤修复 肿瘤 心脏疾病 |
| 收稿时间： | 2014-01-06 |
Advance in function of deubiquitination enzyme BRCC36 |
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| LI Ru-jun,GONG Kai-zheng,ZHANG Zhen-gang. Advance in function of deubiquitination enzyme BRCC36[J]. Chinese Journal of Pathophysiology, 2014, 30(9): 1713-1716. DOI: 10.3969/j.issn.1000-4718.2014.09.030 |
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| Authors: | LI Ru-jun GONG Kai-zheng ZHANG Zhen-gang |
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| Affiliation: | Department of Cardiology, The Second Affiliated Hospital of Yangzhou University, Yangzhou 225001, China. |
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| Abstract: | The protein of BRCC36 is a kind of enzyme specifically hydrolyzing K63-linked poly-ubiquitin chain and widely found in a variety of eukaryotic cells. BRCC36 recognizes diverse substrate proteins, and participates in various kinds of pathophysiological responses such as DNA damage repair, cell signal transduction and cell cycle control. It plays an important role in the process of cancer, angiogenesis and cardiac injury. This review discusses the progress in the investigation on BRCC36 protein to provide the necessary information for searching new therapeutic targets of many diseases. |
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| Keywords: | BRCC36 protein Ubiquitination DNA damage repair Neoplasms Heart diseases |
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