小剂量螺内酯与美托洛尔联用在慢性心力衰竭患者治疗中的效果分析

目的评价小剂量螺内酯联合美托洛尔治疗慢性心力衰竭的疗效。方法将本院68例慢性心力衰竭患者随机分成试验组与对照组各34例。对照组采用基础治疗加服美托洛尔,试验组加载螺内酯联用美托洛尔治疗。分别在入组前、用药4个疗程后按NYHA心功能分级标准评估两组患者心功能分级变化,采用化学发光法检测NT-proBNP值并对患者进行心脏彩超检查记录左心室射血分数（以下称射血分数,EF）。结果治疗4个疗程后,试验组的心功能显效率和总有效率显著高于对照组（P〈0.05）;相比于治疗前两组的射血分数均显著升高,而NT-proBNP大幅下降,4个月后试验组血清NT-proBNP显著低于对照组,心脏射血分数略高于对照组。结论螺内酯联合美托洛尔能有效提高美托洛尔治疗慢性心力衰竭的疗效。

The analysis of the effect for the combination application of small doses of spironolactone and metoprolol in the treatment of patients with chronic heart failure

Objective To evaluate the effect for the combination application of small dose of spironolactone metoprolol in the treatment of chronic heart failure. Methods 68 cases of patients with chronic heart failure were randomly divided into two groups, the test group and the control group, and 34 cases in each group. The control group was received basic treatment plus service metoprolol, and the experiment group was taken with spironolactone associated with metoprolol treatment. The change of cardiac function in patients was taken for evaluation with NYHA class standards before enrollment and drug classification change after four courses. Taking chemiluminescence for the detection of NT-proBNP values and patients were taken for echocardiography examination records on left ventricular ejection fraction （hereinafter referred to as the ejection fraction, EF）. Results After four courses of treatment, the efficiency and total efficiency of heart function of the test group was significantly higher than that in the control group（P〈0.05）. Compared with the first two groups before treatment, the ejection fraction was significantly increased, while the NT-proBNP substantial declined. The serum NT-proBNP in the experiment group after four months was significantly lower than the control group, the cardiac ejection fraction was slightly higher than that in control group. Conclusion Spironolactone metoprolol can effectively improve the metoprolol treatment of chronic heart failure.