铜绿假单胞菌1238株对碳青霉烯类抗生素耐药性分析

目的调查武汉大学人民医院近5年铜绿假单胞菌对碳青霉烯类抗生素的耐药率及其变迁情况。方法收集临床分离的铜绿假单胞菌进行培养并行药敏试验。结果分离出铜绿假单胞菌的标本以痰为主(74.80%),主要分布于神经外科(20.27%)和呼吸内科(13.00%)。2006—2010年铜绿假单胞菌对亚胺培南的耐药率依次为17.4%、38.1%、55.5%、27.8%、37.9%(P0.01),对美罗培南的耐药率依次为11.1%、41.0%、41.5%、23.3%、33.1%(P0.01)。结论铜绿假单胞菌对碳青霉烯类抗生素耐药率自2006—2008年呈明显上升趋势,2008—2010年有所下降,临床应根据药敏结果合理用药,以减少和延缓耐药菌株的产生。

Drug resistance analysis of 1238 strains of Pseudomonas Aeruginosa to carbapenems

[Objective]To investigate the drug resistance rate and its change of Pseudomonas Aeruginosa to carbapenems in Renmin Hospital of Wuhan University in the recent 5 years.[Methods]The strains of Pseudomonas Aeruginosa were isolated from clinical specimens,and the drug sensitivity test was conducted.[Results]Most of Pseudomonas Aeruginosa strains were isolated from sputum specimens(74.80%),and mainly distributed in neurosurgery department(20.27%) and respiratory diseases department(13.00%).During 2006-2010,the rate of resistance to imipenem was 17.4%,38.1%,55.5%,27.8% and 37.9% respectively(P<0.01),and the rate of resistance to meropenem was 11.1%,41.0%,41.5%,23.3% and 33.1 % respectively(P<0.01).[Conclusion]The drug resistance rate of Pseudomonas Aeruginosa to carbapenems has apparently increased in the period 2008-2010,and has decreased since 2008.The rational use of antibiotics should be based on susceptibility results,in order to decrease and postpone the generation of drug-resistant strains.