体检人群非酒精性脂肪性肝病检出率及其相关因素分析

目的探讨广东地区不同年龄段体检人群非酒精性脂肪性肝病(NAFLD)患病率及相关因素。方法对20047例体检人群进行B超和血生化学检查。结果本组体检人群NAFLD检出率为13.2%,其中单纯性非酒精性脂肪肝检出率为8.7%(1731/20047),非酒精性脂肪性肝炎为4.5%(910/20047),未检出肝硬化和肝癌;随年龄增长,NAFLD检出率逐渐增高,其中60~70岁年龄组人群检出率为25.6%,50~60岁年龄组为23.8%,与小于30岁组、30-岁组、40-岁组和70-岁组比,差异有统计学意义(分别为4.7%、10.8%、17.6%和18.7%,P<0.01);男性人群NAFLD检出率高于女性(18.8%对7.8%,P<0.01),但在60岁以上人群,男性与女性NAFLD检出率无明显差别(22.1%对22.4%,P=0.883);NAFLD患者合并高血压、高血糖、高甘油三酯血症和高胆固醇血症的发生率均高于无NAFLD人群(35.2%对11.7%,14.4%对2.6%,46.8%对10.1%,31.8%对2.5%,P<0.01)。结论 NAFLD的发病与年龄、性别及高血压、高血糖、高甘油三酯血症和高胆固醇血症等因素相关。

Prevalence and risk factors of non-alcoholic fatty liver disease in checked-up individuals

Objective The aims of this study was to investigate the prevalence and risk factors of non-alcoholic fatty liver disease(NAFLD)in checked-up subjects in Guangdong Province.Methods 20047 subjects were checked-up by ultrasound and blood parameters.Results The prevalence of NAFLD in this subjects was 13.2%,in which the prevalence of NAFLD in male subjects was significantly higher than that in the female subjects(18.8% vs 7.8%,P<0.01);the peak prevalence(23.8% to 25.6%) occurred in persons of 50-to 69-year old age,which were obviously higher than those in the other groups(4.7% in younger than 30,10.8% in younger than 40,17.6% in younger than 50 and 18.7% in older than 79 years of age,P<0.01);Individuals with hypertension,hyperlipidemia and hyperglycemia had higher prevalence of NAFLD than those without(31.3% vs.10.0%,41.3% vs.8.2%,and 27.9% vs.10.6%,P<0.01).Conclusions The prevalence of NAFLD is high in Guangdong Province and there is a closed correlation of NAFLD to hypertension,hyperlipidemia and hyperglycemia.