糖尿病性骨质疏松发病机制的研究进展

糖尿病性骨质疏松(Diabetic osteoporosis,DO)是指糖尿病(Diabetes mellitus,DM)并发的单位体积内骨量减少、骨组织微细结构改变、骨强度减低、骨脆性增加等易发生骨折的一全身性、代谢性骨病,是糖尿病在骨骼系统的重要并发症之一。其主要发病机制为高血糖、钙磷代谢障碍、胰岛素的不足、糖尿病慢性微血管并发症、细胞因子及遗传因素等。目前对DO发病机制研究已成为国内外研究热点,本文对近年来的研究进展作一综述。

The research progress in the mechanism of the development of diabetic osteoporosis

Diabetic osteoporosis(DO) is a general metabolic bone disease caused by diabetes mellitus(DM) with the characteristics of bone mass decreasing,microstructural changes of bone tissue,bone strength decreasing,and bone friability increasing.It is one of the most important complications of DM in skeletal system.The main mechanisms include hyperglycemia,metabolic block of calcium and phosphorus,the shortage of insulin,diabetic chronic microvascular complications,the abnormal of cytokine,and genetic factors.Recently,the research of DO pathogenesis has become the worldwide research highlight.This paper reviews the current research progress.