| 血管内皮细胞损伤在周围动脉粥样硬化闭塞症发病中作用的研究 |
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| 引用本文： | 彭丽萍,左孟华,王春喜.血管内皮细胞损伤在周围动脉粥样硬化闭塞症发病中作用的研究[J].吉林大学学报(医学版),2002,28(1):52-54. |
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| 作者姓名： | 彭丽萍 左孟华 王春喜 |
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| 作者单位： | 1. 吉林大学第一医院呼吸内科,吉林,长春,130021;2. 中国医科大学第一附属医院外三科 |
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| 摘 要： | 目的:探讨血管内皮细胞(VEC)损伤和肿瘤坏死因子(TNF)在周围动脉粥样硬化闭塞症(PASO)发病中的作用.方法:对50例老年PASO患者进行血浆内皮素(ET)、一氧化氮(NO)、TNF及外周循环内皮细胞(CEC)进行检查.结果:50例PASO患者均呈现高ET、高TNF、低NO血症,外周循环血内皮细胞数目明显增加(P＜0.01),且同疾病严重程度密切相关.结论:血管内皮损伤及TNF参与了PASO的形成和发展.
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| 关 键 词： | 周围动脉粥样硬化闭塞症 内皮素 一氧化氮 肿瘤坏死因子 血管内皮细胞 |
| 文章编号： | 1671-587X(2002)01-0052-03 |
| 修稿时间： | 2001年4月15日 |
Sutdy on effect of vascular endotheliocyte damage in pathogenesis of peripheral atherosclerosis obliteration |
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| PENG Li ping ,ZUO Meng hua ,WANG Chun xi.Sutdy on effect of vascular endotheliocyte damage in pathogenesis of peripheral atherosclerosis obliteration[J].Journal of Jilin University: Med Ed,2002,28(1):52-54. |
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| Authors: | PENG Li ping ZUO Meng hua WANG Chun xi |
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| Institution: | PENG Li ping 1,ZUO Meng hua 1,WANG Chun xi 2 |
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| Abstract: | Objective: To study on the clinical value of PASO caused by VEC damage and tumor necrosis factor (TNF). Methods: Detect plasma endotheliosin (ET), nitrogen monoxide (NO), TNF and peripheral circulatory endotheliocyte (CEC) of 50 old patients. Results: High ET, high TNF, low NO and increased CEC were found in 50 patients with PASO, and they were closely associated with the degree of PASO. Conclusion: The damage of VEC and TNF has been involved in the formation and the development of PASO. |
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| Keywords: | PASO ET NO TNF VEC |
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