Mechanism of the protective action of thiol compounds in ethanol-induced liver injury |
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| Authors: | Chisato Hirayama Yukihiro Kishimoto Tadashi Wakushima Yoshikazu Murawaki |
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| Affiliation: | Second Department of Internal Medicine, Tottori University School of Medicine, Yonago 683, Japan |
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| Abstract: | The protective action of cysteine or mercaptopropionylglycine (MPG) in acute ethanol-induced liver injury has been investigated in the rat. Cysteine accelerated clearance of ethanol and acetaldehyde from blood and liver and prevented an increase in hepatic content of triglyceride and serum ornithine carbamoyl transferase activity. MPG accelerated clearance of ethanol and acetaldehyde less efficiently but prevented an increase in these variables to the same degree. The mode of action of thiol compounds in acute ethanol-induced liver injury has been discussed. |
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| Keywords: | Author to whom correspondence should be addressed. |
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