| 冬凌草甲素诱导白血病K562细胞凋亡的机制 |
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| 引用本文： | 刘加军,潘祥林,伍新尧,蔡贵庆.冬凌草甲素诱导白血病K562细胞凋亡的机制[J].肿瘤研究与临床,2003,15(4):222-225. |
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| 作者姓名： | 刘加军 潘祥林 伍新尧 蔡贵庆 |
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| 作者单位： | 1. 中山大学中山医学院,广东,广州,510080
2. 山东大学第二医院,山东,济南,250033 |
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| 摘 要： | 目的：研究冬凌草甲素诱导白血病K562细胞凋亡的机制。方法：以不同浓度的冬凌草甲素作用于体外培养的K562细胞，检测细胞生长抑制率．观察细胞凋亡时的形态学变化．对细胞凋亡前后的端粒酶活性进行检测。结果：冬凌草甲素可显著降低K562细胞的端粒酶活性．抑翻细胞的生长，诱导细胞发生凋亡。并呈现出明显的量-效与时-效关系。结论：冬凌草甲素能抑制K562细胞的生长并诱导细胞发生凋亡．降低细胞端粒酶活性可能是其重要作用机制之一。
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| 关 键 词： | 冬凌草甲素 端粒酶 细胞凋亡 |
| 文章编号： | 1006-9801(2003)04-0222-04 |
| 修稿时间： | 2003年4月27日 |
THE MECHANISM OF APOPTOSIS INDUCED BY ORINDONIN IN K562 CELLS |
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| LIU Jia jun,PAN Xiang lin,WU Xin yao,et al..THE MECHANISM OF APOPTOSIS INDUCED BY ORINDONIN IN K562 CELLS[J].Cancer Research and Clinic,2003,15(4):222-225. |
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| Authors: | LIU Jia jun PAN Xiang lin WU Xin yao |
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| Institution: | LIU Jia jun,PAN Xiang lin,WU Xin yao,et al.Medical College of Sun Yat Sen University |
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| Abstract: | Objective:To study the mechanism of apoptosis induced by Orindonin in K562 cells.Methods:The variation of both morphology and inhibitory rate of K562 cells were observed in culture medium with various concentrations of Oridonin at different time in vitro. The activity of telomerase was detected before and after apoptosis occurred.Results:Oridonin could decrease the activity of telomerase, as well as cause apoptosis and inhibit the growth of K562 cells significantly.The suppression was both time and dose dependent.Conclusion:Orindonin can inhibit the growth of K562 cells and induce apoptosis , decreasing the activity of telomerase may be one of the most important biochemical mechanisms. |
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| Keywords: | Orindonin Telomerase Apoptosis |
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