冠状动脉介入治疗对冠心病血浆单核细胞趋化因子-1和白细胞介素-6水平的影响(英文)

目的:通过测定冠心病病人行冠脉介入治疗(PCI)前后血浆单核细胞趋化因子-1(MCP-1)及白细胞介素-6水平(IL-6),探讨PCI对冠心病人炎症指标及术后再狭窄的影响。方法:连续入选经PCI治疗的单支病变冠心病人60例(PCI组),30例冠脉造影证实为冠脉正常的正常对照组。采用酶联免疫吸附法检测PCI组治疗前后,正常对照组冠脉造影前后血浆MCP-1和IL-6水平。结果:与术前比较,PCI组病人术后血浆MCP-1(17.38±4.58)pg/L比(20.51±4.61)pg/L]、IL-6(14.59±4.62)pg/mL比(18.87±4.92)pg/mL]水平显著升高(P均<0.01),而正常对照组冠状动脉造影术前后MCP-1、IL-6水平无明显差异(P>0.05)。PCI组病人术后血浆MCP-1和IL-6水平显著高于正常对照组冠脉造影后(P<0.05).结论:冠脉介入治疗后冠心病人的血浆单核细胞趋化因子-1(在炎症反应中起核心调控作用)及白细胞介素-6(炎症反应的中枢性调节因子)水平升高,提示二者与冠脉介入治疗后支架内再狭窄有关。

Influence of percutaneous coronary intervention on plasma levels of monocyte chemotactic factor-1 and interlekin-6 in patients with coronary heart disease

Objective： To investigate influence of percutaneous coronary intervention （PCI） on inflammatory indexes and postoperative vascular restenosis in patients with coronary heart disease （CHD） through measuring plasma levels of monocyte chemotactic factor-1 （MCP-1） and interlekin-6 （IL-6） before and after PCI. Methods： A total of 60 CHD patients undergoing PCI with single vessel coronary disease were consecutively enrolled as PCI group, and 30 subjects with normal coronary artery proved by coronary angiography （CAG） were regard as normal control group. Enzyme linked immunosorbent assay （ELISA） was used to measure plasma MCP-1 and IL-6 levels before and after PCI, CAG in PCI group, normal control group respectively. Results： Compared with before PCI, there were sig- nificant increase in plasma levels of MCP-1 （17.38±4.58） pg/L vs. （20.51±4.61） pg/L] and IL-6 （14.59± 4.62） pg/ml vs. （18.87±4.92） pg/ml] after operation in PCI group （P〉0.01 both）. There were no significant difference in MCP-1 and IL-6 levels in normal control group before and after CAG （P〉0. 05）. The MCP-1 and IL- 6 levels after PCI in PCI group were significant more than those of normal control group after CAG （P〈 0.05）. Conclusion： Plasma levels of MCP-1 （plays a core regulative role in inflammatory reaction） and IL-6 （a central ad- justment factor in inflammatory response） increased in patients with coronary heart disease after PCI, suggesting MCP-1 and IL-6 correlate with in-stent restenosis after PCI.