短暂性脑缺血发作患者纤维蛋白原和C-反应蛋白的检测及其临床意义

目的:观察短暂性脑缺血发作(TIA)患者卒中危险程度与血浆纤维蛋白原(FIB)含量和C-反应蛋白(CRP)水平的关系并探讨其临床意义。方法:60例TIA患者按TIA后预测短暂脑卒中危险性的ABCD评分系统,被分为高危卒中组(ABCD评分>4分,32例),非高危卒中组(TIA组,ABCD评分≤4分,30例),另30例健康体检者作为健康对照组。分别测量各组对象的血浆FIB、血清CRP水平并作比较。结果:高危卒中组血浆FIB水平[(4.6±1.2)g/L]、血清CRP水平[(32.12±6.3)mg/L]明显高于TIA组[(3.6±0.2)g/L、(6.20±4.5mg/L)]及健康对照组[(3.1±0.3)g/L、(5.4±4.8)mg/L],P<0.05或P<0.01。Pearson直线相关分析表明,高危卒中组血浆FIB与血清CRP水平呈正相关(r=0.61,P<0.01)。结论:不同卒中危险程度短暂性脑缺血发作患者血浆纤维蛋白原和血清C-反应蛋白水平存在显著差异。C-反应蛋白与纤维蛋白原可作为早期预测短暂性脑缺血发作患者发生脑卒中风险的生化指标。

Detection and significance of plasma levels of C-reactive protein and fibrinogen in patients with transi- ent ischemic attack and its clinical significance

To observe correlation among plasma fibrinogen （FIB） concentration, level of C-reactive pro-tein （CRP） and risk degree of stroke in patients with transient ischemic attack （TIA）, and explore its clinical signif- icance. Methods： A total of 60 TIA patients were divided into stroke high-risk group （ABCD scores 〉4, 32 cases） and stroke non-high-risk group （TIA group, scores ≤4, 30 cases） according ABCD （based on age, blood pres- sure, clinical features and duration ） scoring system for prediction of short-term risk of stroke after TIA. Another 30 healthy subjects were regard as healthy control group. Plasma FIB level and serum CRP level were measured and compared among three groups. Results： Plasma FIB level [ （4. 6 ± 1.2） g/L] and serum CRP level [ （32.12 ± 6. 3） mg/L] in stroke high-risk group were significantly higher than those of TIA group [ （3.6± 0.2） g/L, （6.20 ±4. 5 mg/L）] and healthy control group [（3.1 ± 0.3） g/L, （5.4 ±4.8） mg/L], P〈0.05, or P〈0.01. Pearson linear correlation analysis indicated that plasma FIB was positively correlated with serum CRP level in stroke high -risk group （r = 0.61, P〈0.01）. Conclusion： There are significant differences in plasma fibrinogen and serum C-reac- tive protein levels among TIA patients with different stroke risk degree. C-reactive protein and fibrinogen can be used as biochemical indexes for early prediction of stroke risk in TIA patients.