替米沙坦对男性高血压患者性功能影响的研究(英文)

目的:探讨替米沙坦对男性高血压患者性功能的影响。方法:选择150例男性高血压患者为研究对象,随机分为替米沙坦组(75例)和贝那普利对照组(75例),观察并比较两组血压、勃起功能国际指数(IIEF)和性生活情况。结果:治疗后两组患者血压均明显下降(P<0.05),且治疗后两组患者血压情况仍无显著差异(P>0.05);治疗后,与贝那普利对照组比较,替米沙坦组IIEF评分[(11.28±1.32)分比(19.48±2.49)分]、性生活频率[(2.09±0.22)次/月比(6.31±0.85)次/月]明显升高,能够勃起比例(62.7%比82.7%)明显增大(P均<0.05);勃起功能情况[分正常,轻、中、重度障碍(ED),χ2=6.322,P=0.0412]及主观性欲要求(分强、中、弱,χ2=7.493,P=0.0326)替米沙坦组亦明显好于贝那普利对照组。结论:替米沙坦能够在保证降压效果的基础上,改善性功能和性生活质量。

Effects of teimisartan on sexual function of male hypertension patients

Objective： To explore influence of telmisartan on sexual function in male patients with hypertension. Methods： A total of 150 male patients with hypertension were enrolled and randomly divided into telmisartan group （n= 75） and benazepril control group （n= 75）. Blood pressure, international index of erectile function （IIEF） and quality of sex were observed and compared between two groups. Results： After treatment, there was significant de- crease in blood pressure in both groups （P〈0.05）, and there was still no significant difference in blood pressure be- tween two groups （P〉0.05） ; compared with benazepril control group, there were significant increase in IIEF score [ （11.28±1.32） scores vs. （19.48±2.49） scores], sex life frequency [（2.09±0.22） times/month vs. （6.31± 0.85） times/month] and erectile proportion （62.7% vs. 82.7%）, P〈0.05 all in telmisartan group; Erectile func- tion （was divided into normal, mild disability, moderate disability and severe disability, X2 = 6. 322, P = 0. 0412） and subjective sexual desire （was divided into strong, middle and weak, X2 = 7. 493, P = 0. 0326） of telmisartan group were also significantly better than those of benazepril control group. Conclusion： Telmisartan can improve sexual function and quality of sex life based on guaranteed antihypertensive effect.