Synthesis and microbiological activity of thiourea derivatives of 4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione |
| |
| Authors: | Marta Struga Szymon Rosolowski Jerzy Kossakowski Joanna Stefanska |
| |
| Affiliation: | (1) Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India;(2) Pharmacology Division, Central Drug Research Institute, Lucknow, 226001, India |
| |
| Abstract: | A series of thiourea derivatives of 4-azatricyclo[5.2.2.02,6]undec-8-ene-3,5-dione were synthesized. The compounds were investigated for antibacterial activity, including Gram-positive cocci, Gram-negative rods, and antifungal activity. Compounds 1b, 2b, 4b showed significant inhibition against Gram-positive cocci. Research was carried out over 10 standard strains and 20 hospital strains. Synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
