心血管疾病中TNF等细胞因子水平的观察

应用双抗体夹心法检测44例心血管疾病（其中冠心病26例,风心病10例,高血压病8例）患者血清肿瘤坏死因子（TNF）、白细胞介素6（IL-6）和白细胞介素8（IL-8）水平。结果显示,心血管病患者血清TNF、IL-6和IL-8水平均显著高于正常人（P<0.002,<0.005和<0.05,不同心血管疾病间TNF、IL-6和IL-8水平无显著性差异（P>0.05）,INF与IL-6和IL-8及IL-6与IL-8之间均成正相关（r分别为0.546、0.394和0.606,P为<0.001、<0.01和<0.001）。提示TNF、IL-6和IL-8可能参与某些心血管疾病的发病及病理变化过程。

Observations on Cytokine Levels in Cardiovascular Diseases

To study the relationships of cardiovascular diseases and cellular factors as well as its clinical significance, the levels of serum tumor necrosis factor (TNF), interleukin 6 (IL-6) and interleukin 8 (IL-8)in 44 patients with cardiovascular diseases were measured by sandwich enzyme linked immunosorbent assay (ELISA). The results showed that the levels of serum TNF, IL-6 and IL-8 in patients with cardiovascular disease were significantly higher than those in the controls(P<0.02, <0.005 and <0.05).No statistical significance in the levels of TNF, IL-6 and IL-8 were found among different cardiovascular diseases(P>0.05). TNF was shown positively correlated with IL-6 and IL-8 (r = 0.546, 0.394, P<0.001,<0.01),and IL-6 positively correlated with IL-8 (r=0.606,P<0.01). It is suggested that TNF, IL-6 and IL-8 may be associated with the pathogenesis and pathobiology of some cardiovascular diseases.