纳洛酮佐治新生儿缺血缺氧性脑病

目的：探讨纳洛酮对新生儿缺血缺氧性脑病的治疗作用。方法：59例中度缺血缺氧性脑病患儿分为两组。对照组35例给予常规治疗，治疗组24例在常规治疗的基础上加用纳洛酮。比较两组中枢抑制改善的时间及治疗组使用纳洛酮前后血压的变化。结果：治疗组的中枢抑制时间短于对照组（P＜0．05），治疗组使用纳洛酮后血压较用药前明显增高（P＜0．05）。结论：纳洛酮在一定程度上能改善新生儿缺血缺氧性脑病的病情，促进其恢复。

Naloxone in the adjunctive treatment of ischemic hypoxic cerebropathy

Objective:To investigate the therapeutic effect of naloxone on ischemic hypoxic cerebropathy in neonates.Methods:Fifty-nine neonates with moderate ischemic hypoxic cerebropathy were divided into 2 groups. Conventional treatment was given to 35 patients of control group, and in 24 patients of treatment group, naloxone was given in addition to conventional treatment. Compared the time to improvement in central nervous suppression between the 2 groups and change in blood pressure before and after naloxone treatment in the treatment group.Results:The central suppression time of the treatment group was shorter than that of control group(P<0.05), and the blood pressure of treatment group was significantly increased after naloxone treatment(P<0.05). Conclusion:Naloxone can improve the conditions of ischemic hypoxic cerebropathy in neonates to a definite degree and facilitates recovery.