Effect of antipyrine on prostaglandin levels and uterine and umbilical blood flow |
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| Authors: | K A Cashner C A Skillman D Brockman C Mack K E Clark |
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| Affiliation: | 1. Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA;2. Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53715, USA;3. Department of Veterinary Integrative Biosciences and Department of Animal Science, Texas A&M University, College Station, TX 7784, USA;4. Division of Obstetrics, Gynecology, and Women’s Health, University of Missouri, Columbia, MO 65211, USA;1. Department of Dairy Science, University of Wisconsin–Madison, Madison, Wisconsin, USA;2. Department of Agricultural and Animal Sciences, Universidad Francisco de Paula Santander, Cúcuta, Colombia;1. Center for Nutrition and Pregnancy, and Department of Animal Sciences, North Dakota State University, Fargo, ND 58108-6050, USA;2. Nutrition, Growth, and Physiology Research Unit, USDA/Agricultural Research Service, U.S. Meat Animal Research Center, Clay Center, NE 68933-0166, USA;3. Department of Animal Science, University of Tennessee Knoxville, Knoxville, TN 37996-4500, USA;4. Department of Animal Science, University of Nebraska Lincoln, Lincoln, NE 68583-0908, USA;5. Department of Animal Science, South Dakota State University, Brookings, SD 57006, USA;6. Department of Animal Sciences, Auburn University, Auburn, AL 36832, USA;1. CEFIVA-Centro de Fertilización In vitro de Asturias, Spain;2. Laboratory of Equine Reproduction and Equine Spermatology, Veterinary Teaching Hospital, University of Extremadura, Cáceres, Spain;1. Embrapa Gado de Leite, Juiz de Fora, MG, Brazil 36038-330;2. Universidade Federal Fluminense, Niterói, RJ, Brazil 24230-340;3. Universidade Jose do Rosario Vellano, Alfenas, MG, Brazil 37130-000;4. Embrapa Rondônia, Porto Velho, RO, Brazil 76815-800;5. Embrapa Caprinos e Ovinos, Sobral, CE, Brazil 62010-970;6. Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil 70770-917 |
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| Abstract: | Antipyrine and 4-aminoantipyrine have been used for approximately 20 years to measure uterine and umbilical blood flow. Fetal infusion of 4-aminoantipyrine has been shown to decrease myometrial activity and to significantly lower prostaglandin F2 alpha metabolite levels. Since prostaglandins are thought to be important in regulating uterine and umbilical blood flow, their decrease could cause significant changes in blood flow. The purpose of the present study was to evaluate the effects of antipyrine on uterine and umbilical blood flow as measured with electromagnetic flow probes and to determine whether antipyrine causes significant changes in levels of prostaglandin E2, prostaglandin F2 alpha metabolite, and prostaglandin I2 measured as 6-keto-prostaglandin F1 alpha. Antipyrine infusion produced significant reductions in the uterine venous levels of prostaglandin E2 and prostaglandin F2 alpha metabolite (p less than 0.05). These reductions in prostaglandin levels were not associated with any significant changes in maternal blood pressure, heart rate, uterine blood flow, or oxygen content. Although fetal prostaglandin levels tended to decrease during the antipyrine infusion, these changes were not significant. Fetal blood pressure, heart rate, umbilical blood flow, PaO2, and oxygen content were not significantly altered. These data suggest that the antipyrine method does not affect basal blood flow in the uterine or umbilical circulation even though uterine prostaglandin levels are significantly decreased. |
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