还原型谷胱甘肽对急性心肌梗死患者超敏C-反应蛋白及心功能的影响

目的研究还原型谷胱甘肽对急性心肌梗死（AMI）患者超敏C-反应蛋白（hs—CRP）及心功能的影响。方法将AMI患者56例随机分为2组，对照组给予常规治疗；研究组除常规治疗外，加用还原型谷胱甘肽。检测血清中hs—CRP、血糖、血脂、心肌酶、肌钙蛋白及心脏彩超等，进行对比。结果与对照组相比，研究组血清中hs—CRP明显降低（4．89±1．90，2．55±1．93，P〈0．05），心脏彩超显示左心室舒张末期容积（LVEDV）（108．96±21．79，92．63±23．51）、心室快速充盈期与心房收缩期血流速度比值（E／A）（0．73±0．08，0．96±0．07）和左心室射血分数（LVEF）（46．69±13．84，59．73±12．78）均有明显改善，差异有统计学意义（P〈0．05）。结论还原型谷胱甘肽能显著降低AMI患者体内hs-CRP的表达，并对改善心功能有一定的作用。

Effect of reduced glutathione on high sensitive C-reactive protein and cardiac function in patients with acute myocardial infarction

[ Objective] To study the effect of reduced glutathione on high sensitive C-reactive protein （hs-CRP） and cardiac func- tion in patients with acute myocardial infarction （AMI/. [ Methods ] 56 AMI patients were randomly divided into two groups, the control group was given the conventional therapy, and the study group was treated with reduced glutathione on the basis of conven- tional therapy. The levels of serum hs-CRP, blood glucose, blood lipid, myocardial enzyme and troponin, as well as ultrasonic car- diogram were tested, and the results were compared between two groups. [ Results ] The level of serum hs-CRP in the study group （ 2.55 ± 1.93 ） was significantly lower than that in the control group （4.89 ± 1.90 } significantly （ P 〈 O. 05 ）. The ultrasonic cardi- ogram showed that LVEDV （ 92.63 ± 23.51 }, E/A （ 0.96 ± 0.07 } and LVEF （ 59.73 ± 12.78 ） in the study group were better than those in the control group （ LVEDV was 108.96 ± 21.79, E/A was 0.73±0.08 and LVEF was 46.69 ± 13.84 } , and the differences were significant （P 〈0.05}. [ Conclusion] The reduced glutathione can significantly reduce the hs-CRP expression in AMI patients, and improve their cardiac function.