| 褪黑素对吗啡戒断小鼠前列腺和睾丸的组织学影响 |
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| 引用本文： | 田素民,李银生,唐岩,李枫,邱学才. 褪黑素对吗啡戒断小鼠前列腺和睾丸的组织学影响[J]. 中国药物依赖性杂志, 2001, 10(1): 36-38,42 |
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| 作者姓名： | 田素民 李银生 唐岩 李枫 邱学才 |
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| 作者单位： | 1. 河南新乡医学院, 新乡, 453003
2. 北京大学医学部生理系, 北京, 100083 |
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| 基金项目： | 天津药物及仿生药物国家重点实验室资助项目 |
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| 摘 要： | 目的··:观察褪黑素 (melatonin,MT)对吗啡戒断小鼠前列腺及睾丸的组织学影响。方法··:设立对照组 (A)和实验组 (B、C、D) ,实验组分别皮下注射定量吗啡 ,建立吗啡依赖模型 ,A组皮下注射等量生理盐水 ,B组继续注射吗啡 ,C组自然戒断 ,D组自然戒断后给MT。实验后将前列腺及睾丸作HE染色 ,光镜观察 ,并进行图象分析。结·果·:吗啡依赖组小鼠前列腺和睾丸组织有不同程度萎缩 ;吗啡戒断组小鼠前列腺组织有明显增生 ,睾丸组织有轻度增生 ;吗啡自然戒断后给MT组小鼠前列腺和睾丸组织基本正常。结论··:MT可抑制吗啡戒断小鼠前列腺和睾丸组织的增生。
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| 关 键 词： | 褪黑素 吗啡戒断 前列腺 睾丸 |
EFFECT OF MELATONIN ONHISTOLOGICAL CHANGES OF PROSTATE AND TESTIS IN MORPHINE WITHDRAWAL MICE |
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| TIAN Sumin,LI Yinsheng,TANG Yan,LI Feng,QIU Xuecai. EFFECT OF MELATONIN ONHISTOLOGICAL CHANGES OF PROSTATE AND TESTIS IN MORPHINE WITHDRAWAL MICE[J]. Chinese Journal of Drug Dependence, 2001, 10(1): 36-38,42 |
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| Authors: | TIAN Sumin LI Yinsheng TANG Yan LI Feng QIU Xuecai |
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| Affiliation: | TIAN Sumin1,LI Yinsheng1,TANG Yan2,LI Feng2,QIU Xuecai21 |
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| Abstract: | Objective: To observe the histological effect of melatonin on prostate and testis in morphine withdrawal mice. Method: A physical dependent model in mice was established by subcutaneous injection of morphine. The histological changes in prostate and testis were observed with microscope. Result: The prostate and testis in morphine dependent mice were atrophied. A multiplication of prostate could be observed in natural morphine withdrawal mice and multiplication of prostate and testis could be inhibited by melatonin. Conclusion: The multiplication of prostate in morphine withdrawal mice could be inhibited by melatonin . |
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| Keywords: | melatonin morphine withdrawal prostate testis |
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