非甾体抗炎药致上消化道出血的相关性研究

目的 探讨非甾体抗炎药(NSAIDs)致上消化道出血的临床特点及相关原因.方法 调查上消化道出血528例患者的临床资料,根据入院前有无服用NSAIDs史将患者分为NSAIDs组(116例)和非NSAIDs组(412例),对两组患者的临床资料进行分析比较.结果 两组患者在性别构成、是否有吸烟史、是否有溃疡史等方面比较差异无统计学意义(P>0.05);NSAIDs组患者的年龄(57.4±12.1)岁,有幽门螺杆菌感染史者占65.5%(76/116),均较非NSAIDs组的(44.6±11.9)岁、25.0%(103/412)高(P<0.01);糜烂、多发、复合型溃疡病灶在NSAIDs组更多见(P<0.01或<0.05).结论 应加强对NSAIDs相关性上消化道出血临床特点的认识,尽量减少NSAIDs的不良反应.

Research on the relation between upper gastrointestinal bleeding and non-steroidal anti-inflammatory drugs

Objective To investigate the clinical features and the correlated reason of upper gastrointestinal bleeding (UGIB) induced by non-steroidal anti-inflammatory drugs (NSAIDs). Methods Five hundred and twenty-eight patients were divided into two groups according to consumption of NSAIDs in the week previous to the onset of bleeding, 116 cases were in NSAIDs group and 412 cases were in non-NSAIDs group. The clinical data was analysed and compared between two groups. Results There was no significant difference in sex, smoking history, and ulcer history between two groups (P> 0.05). The average age was (57.4 ± 12.1) years old and the infection of Hp was 65.5% (76/116) in NSAIDs group, and they were higher than those in non-NSA1Ds group (44.6 ± 11.9) years old and 25.0% (103/412)](P < 0.01). More gastric ulcer and complex ulcer was seen in NSAIDs group (P <0.01 or <0.05). Conclusion Recognition about the clinical characteristics of NSAIDs relevance UGIB should be strengthened, and side effect of NSAIDs should be reduced as far as possible.