Effect of survivin on tumor growth of colorectal cancer in vivo
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| Authors: | Yongping Cai Wei Ma Xiaojuan Huang Liyu Cao Hao Li Yan Jiang Nana Lu Yu Yin |
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| Affiliation: | 1Department of Pathology, Anhui Medical University, Hefei 230032, Anhui Province, China;2Department of Pathology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;3Department of Pathology, The First People’s Hospital, Hefei 230061, Anhui Province, China |
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| Abstract: | Survivin, a member of the inhibitor of apoptosis gene family regulates two critical processes in neoplastic transformation, namely, cell proliferation and apoptosis. This study aimed to detect the effect of survivin on tumor growth of colorectal cancer (CRC) in vivo. We found that inhibition of survivin by interference decreased the sizes and weights of xenografts in nude mice. The number of apoptotic cells of the shRNA survivin group was higher than that of the black group and the shRNA control group. The downregulated expression of survivin decreased the expression levels of bcl2 and ki67. Our results indicated that inhibition of survivin significantly enhanced the inhibition of tumor growth and induced apoptosis. Survivin is an attractive target for CRC treatment. |
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| Keywords: | Survivin colorectal cancer RNA interference proliferation apoptosis |
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