Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer |
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| Authors: | Yingchi Yang Jun Cai Jie Yin Dong Wang Zhigang Bai Jun Zhang Kangli Wang Guanzhen Yu Zhongtao Zhang |
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| Affiliation: | 1Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;2Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center of Digestive Diseases, Beijing 100050, China;3Department of Medical Oncology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China |
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| Abstract: | Inorganic pyrophosphatase (PPA1) is an enzyme which has been found to be upregulated in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated. In present study, gastrointestinal tissue microarrays were used to evaluate PPA1 expression and the association of PPA1 expression with clinical outcomes was determined for patients with gastric cancer by immunohistochemistry. Overexpression of PPA1 was observed in cancers of the esophagus, stomach, and pancreaticobiliary system. PPA1 was overexpressed in 143 cases (51.3%) of the 279 primary gastric tumors and was associated with larger size (> 3 cm), nodal metastasis and advanced clinical staging (P < 0.05). Moreover, survival analysis demonstrated that PPA1 expression was significantly correlated reduced overall of patients with gastric cancer. Therefore, PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer. |
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| Keywords: | Gastric cancer PPA1 metastasis |
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