Association between IL-10 gene polymorphisms and the risk of ischemic stroke in a Chinese population |
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| Authors: | Wen He Haiyan Song Lihong Ding Cunbao Li Lina Dai Shang Gao |
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| Institution: | 1Department of Neurology, Bayannaoer Hospital, Bayannaoer, China;2Department of Internal Medicine, Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China;3Department of Biochemical and Molecular Biology, Inner Mongolia Medical University, Hohhot, China;4Department of Anthropotomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, China |
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| Abstract: | We investigated the possible association between two SNPs of IL-10 (IL-10 -1082A/G and -819T/C) and the susceptibility to ischemic stroke. Patients with proven ischemic stroke and control subjects were recruited between March 2013 and May 2015. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Conditional logistic regression analyses revealed that the GA and the AA genotypes were associated with development of ischemic stroke, and the ORs (95% CI) for the GA and the AA genotypes of IL-10 -1082A/G were 1.49 (1.01-2.19) and 1.83 (1.02-3.29) compared with the GG genotype, respectively. In dominant model, the GA+AA genotype of IL-10 -1082G/A was correlated with increased risk of ischemic stroke compared to the GG genotype (OR=1.56, 95% CI=1.08-2.25). The GA+AA genotype was associated with moderately increased risk of ischemic stroke in smokers (OR=1.72, 95% CI=1.04-2.84). In conclusion, our study suggests that IL-10 gene polymorphisms contribute to the development of ischemic stroke, especially in tobacco smokers. |
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| Keywords: | IL-10 polymorphism ischemic stroke |
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