炎症细胞因子在COPD患者治疗前后的变化 |
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引用本文: | 叶军辉,余贤广,凌杰.炎症细胞因子在COPD患者治疗前后的变化[J].中国现代医生,2012,50(23):29-30. |
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作者姓名: | 叶军辉 余贤广 凌杰 |
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作者单位: | 浙江省三门县人民医院呼吸内科;浙江省台州市第一人民医院检验科 |
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基金项目: | 2006年浙江省台州市科技计划项目(第一批)(061KY68) |
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摘 要: | 目的探讨炎症细胞因子在慢性阻塞性肺疾病患者治疗前后的变化。方法选择45例急性发作期的COPD患者(观察组),入院后予以吸氧、抗感染、止咳化痰及平喘等常规对症治疗1周。观察治疗前后血浆肿瘤坏死因子-α(TNF-α)、转化生长因子(TGF-β1)和白介素~IO(IL-10)水平的变化。另选择我院体检中一t7正常的健康体检者30例作为对照组。结果观察组的血浆TNF-α和TGF-β1水平明显高于对照组,IL-10水平明显低于对照组(均P〈0.01);治疗1周后,观察组的血浆TNF-α和TGF-β1水平较治疗前明显下降,血浆IL-10水平较治疗前明显上升(均P〈0.01)。结论TNF-α、TGF-β1和IL-10参与了COPD发病过程,通过调节血浆炎症细胞因子的水平,为COPD治疗提供新的思路。
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关 键 词: | 慢性阻塞性肺疾病 肿瘤坏死因子-α 转化生长因子-β1 白介素-10 |
Changes of plasma cytokines in patients with chronic obstructive pulmonary disease before and after treatment |
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Authors: | YE Junhui YU Xianguang LING Jie |
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Institution: | 1.Department of Respiratory Medicine,the People′s Hospital of Sanmen County in Zhejiang Province,Sanmen 317100,China;2.Department of Clinical Laboratory,the First People’s Hospital of Taizhou City in Zhejiang Province,Taizhou 318020,China |
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Abstract: | Objective To explore the changes of plasma cytokines in patients with chronic obstructive pulmonary disease before and after treatment.Methods Forty-five patients with COPD in acute stage were choosed as observing group,and all patients got treatments as oxygen,antibiotics,drugs for relieving cough,sputum and asthma,and other symptomatic and supportive treatment for 1 week.The plasma levels of TNF-α,TGF-β1 and IL-10 were observed before and after treatment.30 normal people were choosed as control group.Results The levels of TNF-α and TGF-β1 of observing group were significantly higher than that of control group,but the level of IL-10 was the opssite(all P < 0.01).1 week after treatment,compared to that before treatment,the levels of TNF-α and TGF-β1 of observing group descended significantly,and the level of IL-10 rised significantly(all P < 0.01).Conclusion TNF-α,TGF-β1 and IL-10 participate in the progress of COPD.Maybe it is a new thinking to treat the COPD by regulating the level of cytokines. |
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Keywords: | Chronic obstructive pulmonary disease TNF-α TGF-β1 IL-10 |
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