良性前列腺增生病人血清IGF-1、IGFBP-3水平分析

目的 :检测良性前列腺增生 (BPH)病人血清胰岛素生长因子 Ⅰ(IGF 1 )及其结合蛋白 3 (IGFBP 3)的水平 ,探讨IGF 1、IGFBP 3对揭示BPH病因及治疗方面的价值。　方法 :采用免疫放射分析法 (IRMA)测定 64例BPH病人血清中IGF 1、IGFBP 3水平 ,并以 30例健康男性作对照。BPH病人按照其前列腺总体积 (PV)的大小分为 3组 :A组PV≤ 30ml,1 8例 ;B组　PV 31～ 50ml,2 4例 ;C组　PV≥ 50ml,2 2例。　结果 :BPH组血清IGF 1、IGFBP 3含量与对照组比较 ,差异均无显著性。BPH组中 ,C组与A组比较 ,IGF 1、IGFBP 3水平均显著升高 (P<0 .0 5) ,C组与B组比较 ,IGF 1水平显著增高 (P =0 .0 0 3) ,IGFBP 3水平无统计学差异。IGF 1、IGFBP 3的水平随PV的增加而升高 ,均呈正相关 (r =0 .58,r =0 .48)。　结论 :IGF 1、IGFBP 3水平的高低与前列腺增生的程度有关 ,对BPH病因的揭示及BPH的非手术治疗均有一定的临床价值

Analysis of Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 in Benign Prostatic Hyperplasia

OBJECTIVES: To determine changes of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in serum samples from benign prostatic hyperplasia (BPH) patients and to evaluate the value of these molecules as possible etiologic factors for BPH. METHODS: The serum IGF-1 and IGFBP-3 levels were measured with immunoradiometric assay(IRMA) in 64 cases of BPH and in 30 healthy subjects as controls. The cases of BPH were divided into 3 groups according to the prostate volume(PV). There were 18 cases(PV < or = 30 ml) in group A, 24 cases(PV31 approximately 50 ml) in group B, 22 cases(PV > or = 50 ml) in group C. RESULTS: There were no statistical differences between the levels of Both IGF-1 and IGFBP-3 in BPH groups and healthy groups (both P > 0.05), but there were statistical differences among three groups of BPH. Both IGF-1 and IGFBP-3 levels in group C of BPH were significantly higher than those in group A (both P < 0.05). A positive correlation between the serum levels of IGF-1 and PV displayed(r = 0.58), as well as IGFBP-3 (r = 0.48). CONCLUSIONS: Together these observations implicate IGF-1 and IGFBP-3 as important factors during the progression of BPH. It shows the value of non-operation treatment for this disease.