Chromosomal sublocalization of human gene sequences by in situ hybridization |
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| Authors: | Hsiao-chen Chang Douglas J. Jolly Eva Biro Oliver W. Jones Theodore Friedmann |
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| Affiliation: | (1) Department of Medicine, University of California, 92093 San Diego, La Jolla, California;(2) Department of Pediatrics, University of California, 92093 San Diego, La Jolla, California |
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| Abstract: | Summary The procedure for human gene mapping by in situ hybridization is described. By using specific radiolabeled probes, specific homologous sequences can be localized as silver grains on chromosome spreads of cytogenetic preparations. It is therefore possible to obtain genetic information on translocation, breakpoint, deletion, amplification, and rearrangement at the chromosomal level of many human diseases. |
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| Keywords: | gene mapping in situ hybridization radiolabeled probe gene sequences chromosomal localization |
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