酪氨酸与乙酰唑胺对高原负荷运动后光觉功能的影响

目的 :探讨药物对高原低氧条件下负荷运动后人体光觉功能的影响。方法 :选择驻守海拔 370 0m6个月的汉族男性青年 2 0人 ,分甲、乙两组分别口服酪氨酸与乙酰唑胺。于服药前、服药15天和停药 10天三个阶段时采用EGM型脚踏车功量仪进行达负荷指标的运动 (负荷指标 :W 2 2 5 ,P 175～ 180次 分 ) ,于每次运动后 15分钟 ,应用暗房夜光表测验法[1] ,检测观察暗适应反应时间。结果 :海拔 370 0m服药前运动前、暗适应反应时间显著长于平原人 (P <0 .0 1)。服药前运动后暗适应时间显著长于服药前运动前 (P <0 .0 1) ;停药 15d运动后暗适应时间显著短于服药前运动前、后与停药 10d运动后 (P <0 .0 1)。停药 10天运动后与服药前运动后比较暗适应反应时间显著缩短 (P <0 .0 1)。与服药前运动前比较无显著性差异 (P >0 .0 5 )。结论 :酪氨酸与乙酰唑胺均能有效的改善和提高高原低氧条件下负荷运动前后人体光觉功能

Effect of Tyrosine and Acetazolamide on the Dark Adptation Following Loaded Exercise at High Altitude

Objective: To study the effect of tyrosine and acetazolamide on the dark adaptation following loaded exercise at high altitude. Methods:20 subjects who exposed at an altitudes of 3 700m for six months were divided into tyrosine group and acetazolamide group, they were asked to pedal the bicycle ergometer about 60 rpm, and the exercising resistance was progressively increased by 25W per 3 min up to exhaustion, and to determine the time of dark adaptation before and after taking the test medicine for 15 days, and on the 10th day to have stopped taking medicine. Results: Compared with those in sea level, the time of dark adaptation was prolonged at an altitude of 3 700m. After taking tyrosine and acetazolamide for 15 days, the time was shortened (P< 0.01), and this effective effort could persist about 10 days. Conclusion: Tyrosine and acetazolamide can improve the visual function of subjects under hypoxic environment